摘要
目的探讨血清甲状腺激素（thyroid hormone,TH）水平检测在难治性抑郁症（refractory depression,RD）患者预后评估中的价值。方法选择2014年3月-2016年2月在杭州市第一人民医院接受治疗的108例RD患者,按照随机数字法分为观察组和对照组,每组各54例。观察组给予抗抑郁治疗方案,对照组采用安慰剂治疗。对比2组患者治疗前及治疗后汉密尔顿抑郁量表（HAMD）、汉密尔顿焦虑量表（HAMA）得分变化,及TSH、T3、T4、FT3、FT4水平变化。结果治疗后,观察组HAMD和HAMA得分分别为（14.4±2.5）分和（15.2±2.7）分,对照组为（25.6±5.2）分和（25.9±4.8）分,观察组HAMD和HAMA得分明显低于对照组（P〈0.05）;治疗后,观察组TSH、T3、T4、FT3、FT4水平分别为（4.54±0.68）m IU/L、（1.21±0.56）nmol/L、（55.4±6.1）nmol/L、（3.16±0.42）pmol/L和（8.53±0.62）pmol/L,与治疗前相比,TSH下降明显,而T3、T4、FT3、FT4均明显上升;对照组为（5.16±0.62）m IU/L、（0.91±0.42）nmol/L、（51.9±3.2）nmol/L、（2.82±0.40）pmol/L和（7.76±0.64）pmol/L,与观察组比较差异有统计学意义（P〈0.05）。结论 RD患者症状严重程度与TH水平紧密相关,抗抑郁治疗可以改善TH,从而改善患者症状,在RD治疗过程中,要关注TH水平变化。
Objective To investigate the value of serum thyroid hormone（Thyroid hormone,TH） levels on prognosis in patients with treatmentresistant depression（Refractory depression,RD）. Methods 108 cases of RD patients collected in Hangzhou First People＇s hospital from March 2014 to February 2016 were divided into observation group and control group according to the method of random numbers,and each had 54 patients. Patients in the observation group were given antidepressant treatment program and the control group a placebo. Hamilton Depression Scale（HAMD）,Hamilton Anxiety Scale（HAMA） score changes,and TSH,T3,T4,FT3,FT4 levels of two groups pre- and post-treatment were compared. Results After treatment,the HAMD and HAMA scores in observation group were（14. 4 ± 2. 5） and（15. 2 ± 2. 7） significantly lower than that in control group,which were（25. 6 ± 5. 2） and（25. 9 ± 4. 8）,separately,the differences were significant（P〈0. 05）; the TSH,T3,T4,FT3,FT4 levels in observation group post-treatment were（4. 54 ± 0. 68） m IU/L,（1. 21 ± 0. 56） nmol/L,（55. 4 ± 6. 1） nmol/L,（3. 16 ± 0. 42） pmol/L and（8. 53 ± 0. 62） pmol/L,TSH decreased significantly,and T3,T4,FT3,FT4 were significantly increased than pre-treatment（P〈0. 05）; the indexes in control group were（5. 16± 0. 62） m IU/L,（0. 91 ± 0. 42） nmol/L,（51. 9 ± 3. 2） nmol/L,（2. 82 ± 0. 40） pmol/L and（7. 76 ± 0. 64） pmol/L（P〈0. 05）,the differences with observation group were significant（P〈0. 05）. Conclusion The severity of the symptoms of patients is closely related with TH RD level,antidepressant therapy can improve TH,thereby improving the patient＇s symptoms,so it is important to pay attention to TH levels in the treatment process of RD.
出处
《中国生化药物杂志》
CAS
2016年第9期151-153,共3页
Chinese Journal of Biochemical Pharmaceutics
关键词
甲状腺激素
难治性抑郁症
汉密尔顿抑郁量表
thyroid hormone
refractory depression
Hamilton depression rating scale
