摘要
目的:探讨影响胰岛素泵治疗后1型糖尿病(T1DM)患者血糖达标的因素。方法:采用胰岛素泵治疗的T1DM成人患者100例,根据治疗后糖化血红蛋白(Hb A1c)水平分成达标组(Hb A1c≤7.0%)和未达标组(Hb A1c>7.0%),比较两组患者年龄、病程、体重指数(BMI)、性别比、餐后2h C肽水平、推荐饮食的执行人数、每周不同运动时间人数、血糖监测频次、更换胰岛素输注管路频率、不同受教育程度患者的比例、不同人均年收入家庭比例、胰岛素泵每日基础量、每日总量、基础量/总量比值、每日餐前胰岛素剂量、基础率分段、患者低血糖频率、使用不同类型胰岛素比例及不同慢性并发症患者比例;采用多元回归分析不同Hb A1c含量与影响因素的相关性。结果:达标组患者的胰岛素泵每日基础量、胰岛素泵基础量/胰岛素泵全天总量明显低于未达标组,而血糖监测频次高于未达标组,差异有统计学意义(P<0.05),其余指标比较差异均无统计学意义(P>0.05);多元线性回归分析显示,胰岛素泵治疗的T1DM成人患者血糖达标与性别、血糖监测频次成正相关(β=0.339、0.291,P<0.05),与每日胰岛素泵基础量负相关(β=-1.547,P<0.05)。结论:性别、血糖监测频次与胰岛素每日基础量是胰岛素泵治疗T1DM成人患者血糖达标的影响因素。
Objective：To explore the influencing factors of blood glucose control on T1DM patients with insulin pump therapy. Methods：100 grown-up patients with T1DM in were divided into 2 groups （ Group A：HbA1 c≤7%,Group B：HbA1 c〉7 . 0%）. Clinical data and self-management were col-lected and analyzed between two groups：age,course of diseases,BMI,empty belly C peptide,2 h postprandial c-peptide,adhere to the recommended number of diet,exercise time each week,replace-ment of insulin infusion line frequency,level of education,family income per head,high-dose daily before a meal,segmentation base rate,low frequency,the types of insulin,chronic complications. A-dopting Multivariate Regression Analysis to analyze different HbA1 c content and influencing factors rel-evance. Results：daily insulin pump,basic insulin pump/ whole day content of standard group was obviously lower than substandard group;blood glucose monitoring frequency was higher than substand-ard group,difference was statistically significant（P〈0. 05）;other indexes comparison showed no sta-tistical significane（ P〉0 . 05 ）. Multivariate Regression Analysis showed that insulin pump treatment on T1DM adult patients was positive correlated with gender,blood glucose monitoring frequency,while negative correlated wih daily insulin pump basic content（P〈0. 05）. Conclusion：Gender,blood glu-cose monitoring frequency and insulin daily basis are influencing factors on T1 DM patients with insulin pump therapy.
作者
苏金刚
韩文占
樊锁兵
权海霞
郭明兰
王蓓
SU Jingang HAN Wenzhan FAN Suobing QUAN Haixia GUO Minglan WANG Bei(Department of Endocrinology, Fufeng County People Hospital, Fufeng 722200, Shaanxi, Chin)
出处
《贵州医科大学学报》
CAS
2016年第11期1353-1357,共5页
Journal of Guizhou Medical University
