摘要
目的探讨乌司他丁对蝮蛇咬伤患者肠黏膜屏障功能的影响。方法将62例蝮蛇咬伤患者随机分为治疗组和对照组。两组均采取常规治疗,治疗组加用乌司他丁20万单位静脉缓慢推注,2次/d,连续3 d,对照组加用等量生理盐水作对照,分别于就诊当天及就诊后第3天晨采静脉血,采用改良的酶学分光光度法测定血浆DAO和D-乳酸的含量。结果治疗3 d后,两组患者DAO、D-乳酸含量均显著下降(P<0.05或P<0.01),并且观察组下降幅度较对照组更加明显(P<0.05)。结论乌司他丁对蝮蛇咬伤患者肠黏膜屏障功能有明显保护作用。
Objective To explore the effects of ulinastafin on intestinal mueosa barrier in patients with snake bite. Methods A total of 62 patients with snake bite were randomly divided into treatment group and control group. Both groups received regular therapeutic methods. The ulinastatin of 0.2 million units was used consecutively 3-day by intravenous slowly in the treatment group, and the saline solution was given in the control group. The plasma diamine oxidase （DAO） and D-lactate （D-LAC） levels were detected on treatment and 3 days later. Results The plasma DAO and D-LAC levels reduced significantly 3 days after treatment （P 〈 0.05 or P 〈 0.01）, and there were significant differences between the two groups （P 〈 0.05）. Conclusions Ulinastatin can protect the intestinal mucosa barrier in patients with snake bite.
出处
《中国现代医学杂志》
CAS
北大核心
2016年第20期99-101,共3页
China Journal of Modern Medicine
