摘要
目的探讨急性肺栓塞患者血清同型半胱氨酸(Hcy)、超敏C反应蛋白(hs-CRP)和D-二聚体(DD)联合检测的临床意义。方法选取急性肺栓塞患者50例(观察组),体检健康者48例(对照组)。观察组于入院当天、对照组于体检时取静脉血检测血清Hcy、hs-CRP、DD水平,统计三者阳性率,分析血清Hcy、hs-CRP、DD水平与肺栓塞严重程度的关系。结果观察组血清Hcy、hs-CRP、DD水平及阳性率均高于对照组(P均<0.01)。随肺栓塞严重程度增加,患者血清Hcy、hs-CRP和DD水平均逐渐升高(P均<0.05)。观察组血清Hcy、hs-CRP、DD水平均与肺栓塞严重程度呈正相关(r分别为0.73、0.69、0.76,P均<0.05)。联合检测血清Hcy、hs-CRP、DD水平诊断急性肺栓塞的AUC为0.885、敏感性为0.894、特异性为0.794,均高于三项单独检测。结论急性肺栓塞患者血清Hcy、hs-CRP和DD水平均升高,且均与肺栓塞严重程度呈正相关,三者联合检测可提高急性肺栓塞早期诊断价值。
Objective To investigate the clinical significance of combined detection of homocysteine（ Hcy）,highsensitivity C-reactive protein（ hs-CRP） and D-dimer（ DD） in patients with acute pulmonary embolism（ APE）. Methods Fifty patients with acute pulmonary embolism（ observation group） and 48 healthy individuals（ control group） were included in this study. The plasma levels of Hcy,hs-CRP and DD in the venous blood which was obtained from the observation group on admission and from the control group on examination were detected and the positive rates were calculated to analyze the relationships between Hcy,hs-CRP and DD and the severity of APE. Results The serum levels and the positive rates of Hcy,hs-CRP and DD were statistically higher in the observation group than those of the control group（ all P〈0. 01）. With the increase of APE severity,the serum levels of Hcy,hs-CRP and DD increased as well（ all P〈0. 05）. In the observation group,the serum levels of Hcy,hs-CRP and DD were positively correlated with the severity of APE（ r =0. 73,0. 69 and 0. 76,all P〈0. 05）. AUC of combined detection of Hcy,hs-CRP and DD in diagnosis of APE was0. 885,the sensibility was 0. 894 and the specificity was 0. 794,which was all higher than that of detection alone. Conclusions The serum levels of Hcy,hs-CRP and DD increase in APE patients and are positively correlated with the severity of APE. The combined detection of them may improve the early diagnostic value of APE.
出处
《山东医药》
CAS
北大核心
2016年第36期46-48,共3页
Shandong Medical Journal
基金
承德市科学技术研究与发展计划项目(201601A37)
