摘要
目的:比较栀子不同炮制饮片对四氯化碳(CCl4)致急性肝损伤的保护作用,为栀子不同饮片合理选择提供实验依据。方法:采用四氯化碳致大鼠急性肝损伤模型,测定大鼠血清中ALT、AST、TBIL、DBIL、TBA、LDH、ADA、PA、TP、ALP和肝组织中SOD、MDA的水平,并对肝组织进行病理学检查。结果:栀子不同炮制饮片组中AST、ALT、TBA、ADA、LDH、MDA生化指标均具有显著改善(P<0.05),但对SOD、ALP无影响,肝组织损伤有不同程度减轻。结论:栀子不同炮制饮片均具有降酶保肝作用;但栀子仁较栀子皮的降酶保肝作用强,而栀子生品较炒焦饮片降酶保肝作用更强。
Objective： To provide the experimental evidence for the appropriate selection of the different prepared products from Gardenia jasminoides fruits by comparing their protection effects on carbon tetrachloride（ CCl_4）-induced acute liver injury. Methods： The activities of ALT,AST,ADA,LDH,ALP and contents of PA,TP,TBIL,DBIL,TBA in serum,the activities of SOD and the content of MDA in liver tissue were measured in acute liver injury rats by carbon tetrachloride. Also the pathological changes of liver tissues were examined under microscope. Results： The biochemical indexes of AST,ALT,TBA,ADA,LDH and MDA were significantly improved in all groups of prepared products from Gardenia jasminoides fruits,but not SOD and ALP. The lesions of liver tissue had different degrees of reduction. Conclusion： The different prepared products from Gardenia jasminoides fruits had the effects of liver protection. The nut of Gardeniae Fructus was superior to the peel in enzyme decreasing and liver protection. The crude was superior to the stir-cooked in enzyme decreasing and liver protection.
作者
邵坚
罗光明
朱继孝
杨雅琴
罗扬婧
袁源见
SHAO Jian LUO Guang-ming ZHU Ji-xiao YANG Ya-qin LUO Yang-jing YUAN Yuan-jian(Jiangxi University of Traditional Chinese Medicine, Nanchang 330004, China Jiangzhong Pharmaceutical Limite3 by Share Ltd. , Nanchang 330004, China)
出处
《中药材》
CAS
CSCD
北大核心
2016年第7期1521-1524,共4页
Journal of Chinese Medicinal Materials
基金
国家科技部"十二五"科技支撑计划课题(2011BAI04B01)
国家中医药管理局行业科研专项(201507002-1-02)
关键词
栀子
炮制饮片
四氯化碳致急性肝损伤
Gardenia jasminoides Eills
Different prepared products
CCl4-induced acute liver injury
