摘要
目的 探讨妇科外科手术治疗有生殖要求卵巢恶性生殖细胞肿瘤（malignant ovarian germ cell tumor,MOGCT）患者疗效.方法 选择有生殖要求的MOGCT患者77例,根据所采用的手术方法分为附件切除术组（37例）、分期手术组（31例）和肿物切除术组（9例）,观察各组患者手术时间、术中出血量、妊娠及分娩情况、并发症发生率、复发情况、死亡情况及5年累计生存率.结果 三组患者平均手术时间、术中平均出血量、术后并发症发生率组间比较差异有统计学意义（P＜0.05）;三组患者化疗平均疗程比较差异无统计学意义（P＞0.05）;治疗后妊娠率和分娩率均以附件切除术组（75.68％、72.97％）最高,分期手术组（67.74％、64.52％）次之,肿物切除术组（66.67％、55.56％）最低,组间比较差异无统计学意义（P＞0.05）;三组患者复发率、病死率比较差异有统计学意义（P＜0.05）;附件切除组、肿物切除组和分期手术组5年累计生存率分别为100.00％、100.00％和90.32％,组间比较差异无统计学意义（P＞0.05）;三组5年累计无瘤生存率分别为100.00％、88.89％和83.87％,组间比较差异有统计学意义（P＜0.05）.结论 附件切除术配合PVB化疗方案治疗有生殖要求MOGCT效果理想.
Objective To explore the curative effect of gynecological surgery in the treatment of patients with malignant ovarian germ cell tumor （MOGCT） with reproductive requirement.Methods 77 patients with MOGCT with reproductive requirement were selected,and divided into adnexectomy group （37 cases）,staging surgery group （31 cases）,neoplasms resection group （9 cases） according to the operation methods.Observed operation time,intraoperative blood loss,pregnancy and delivery situation,complications,recurrence,deaths,and cumulative survival rate for five years of three groups.Results There were statistically significant differences in operation time,intraoperative blood loss,the incidence of postoperative complications among three groups （P〈0.05）,no statistically significant difference in the course of chemotherapy among three groups （P〉0.05）.After treatment,the rate of pregnancy and delivery in adnexectomy group were the highest （75.68%,72.97%）,followed by 67.74%,64.52% in staging surgery group,66.67%,55.56% in neoplasms resection group,without statistically significant differences among three groups （P〉0.05）.There were statistically significant differences in the rate of recurrence,case fatality rate among three groups （P〈0.05）.Cumulative survival rate for five years of adnexectomy group,neoplasms resection group,staging surgery group were 100%,100%,90.32%,without statistically significant difference among three groups （P〉0.05）;cumulative disease free survival rate for five years of adnexectomy group,neoplasms resection group,staging surgery group were 100%,88.89%,83.87%,with statistically significant difference among three groups （P〈0.05）.Conclusion Adnexectomy combined with PVB chemotherapy regimen in the treatment of patients with MOGCT with reproductive requirement has ideal effect.
出处
《国际医药卫生导报》
2016年第19期2936-2939,共4页
International Medicine and Health Guidance News
关键词
卵巢恶性生殖细胞肿瘤
生育功能
妇科外科手术
疗效
Malignant ovarian germ cell tumor
Reproductive function
Gynecological surgery
Effect
