摘要
背景 Toll样受体（toll-like receptors,TLRs）作为先天防御的重要组成部分,通过识别病原相关分子模式而发挥重要的固有免疫功能,同时也能触发树突状细胞的成熟而调节获得性免疫.TLRs通过募集细胞内不同的信号分子及其他调控通路控制炎性反应的类型、程度及持续时间. 目的 通过详细阐述TLRs的信号转导通路及其对炎性因子的调控进而对其有更深一步的理解,为合理调控炎性反应提供新思路. 内容 全面阐述TLRs的信号转导通路及其对炎性因子的调控.趋向 TLRs与感染性炎性反应已有较多研究,但与非感染性炎性反应的关系还不明确,尚需进一步研究.
Background Toll-like receptors （TLRs） play crucial roles in the innate immune system by recognizing pathogenassociated molecular patterns derived from various microbes.Meanwhile,TLRs can regulate the acquired immunity by triggering dendritic cells to become maturation.TLRs signal controls the type,degree and duration of inflammatory reaction through the recruitment of specific adaptor molecules and other regulating pathways.Objective To make a elaboration and a further understanding of TLRs signal transduction pathways and the regulation on inflammatory cytokines,to provide new method of reasonable regulation on inflammatory reactions.Content This review will describe recent progress about TLR-signaling pathways and the regulation on inflammatory cytokines.Trend There has been more research about TLRs and infectious inflammatory reaction,but the relationship between TLRs and noninfectious inflammatory reaction is still not clear,and needs further research.
作者
刘燕飞
时飞
Liu Yanfei Shi Fei(Department of Anesthesiology, Qingdao Municipal Hospital, Qingdao 266000, China Department of Graductte, TaiShan Medical University, Taian 271000, China)
出处
《国际麻醉学与复苏杂志》
CAS
2016年第1期86-91,共6页
International Journal of Anesthesiology and Resuscitation
关键词
TOLL样受体
信号转导通路
炎性因子
Toll-like receptors
Signaling pathways
Inflammatory cytokines
