摘要
背景中枢炎症是术后认知功能障碍（postoperative cognitive dysfunction，POCD）的主要病理机制之一。而血脑屏障（blood brain barrier，BBB）结构和功能完整性的破坏在外周手术创伤后发生中枢炎症中发挥着不可或缺的作用。外周创伤后通过各种途径破坏BBB的完整性，导致BBB通透性的改变，引起和扩大中枢炎症，从而影响学习记忆和认知能力。目的探讨BBB在外周致中枢炎症中发挥的作用及其与认知功能的关系。内容主要从3个方面进行论述：中枢炎症与POCD的关系、BBB在外周致中枢炎症中的作用、BBB通透性的改变及其参与者。趋向中枢炎症是POCD的主要病理机制之一。BBB是外周手术致中枢炎症中起关键作用，但外周手术后BBB的变化及其与中枢炎症和认知的具体关系尚不清楚。
Background The central inflammatory response plays an important role in postoperative cognitive dysfunction （POCD）. The disruption of blood brain barrier （BBB） play a key role in central inflammation after the peripheral surgical trauma. The inflammatory cytokines disrupt the integrity of BBB through a variety of pathway, thus causing and expanding the central inflammatory, affecting learning and cognitive abihties. Objective To investigate the role of BBB in central inflammation after the peripheral surgical trauma and the relationship with cognitive function. Content Reviewed mainly from three aspects： the relationship of central inflammation with POCD, the role of BBB in central inflammation induced by peripheral inflammation, the participants that involved in the change of BBB permeability. Trend The central inflammatory response plays an important role in POCD. BBB play a key role in central inflammation induced by peripheral operation But the pathological change of BBB, and its exactly relationship with central inflammation are still unclear.
出处
《国际麻醉学与复苏杂志》
CAS
2015年第8期749-753,共5页
International Journal of Anesthesiology and Resuscitation
基金
国家科学自然基金面上项目（81471410）
关键词
炎症
血脑屏障
认知
Inflammation
Blood brain barrier
Cognitive
