摘要
目的:观察大株红景天注射液对乳腺癌化疗患者的免疫功能的影响及调节作用,并探讨其作用机制。方法:选取2013年6月—2015年6月乳腺癌化疗患者141例,采用随机数字表法分成观察组和对照组。其中观察组69例,脱落病例9例,共完成60例;对照组72例,脱落病例10例,共完成62例。两组均采用紫杉醇联合顺铂6周期方案进行化疗,观察组在化疗基础上加用大株红景天注射液10 d。观察两组患者细胞免疫指标,化疗前1 d及化疗后第10天清晨抽血,采用流式细胞仪分别测定两组患者化疗前后的T细胞亚群CD4^+,CD8^+,CD4^+/CD8^+。观察两组体液免疫指标,化疗前1 d及化疗后第10天清晨抽血,采用免疫透视比浊法定量测定免疫球蛋白(Ig)G,Ig A,Ig M和补体C_3。观察两组药物毒性反应,化疗期间监测患者血常规、肝、肾功能,同时参照《抗癌药物急性与亚急性毒性反应判定标准》记录化疗期间药物毒性反应。化疗后对比两组患者T细胞亚群、体液免疫指标、药物毒性反应变化情况。结果:经过1周期的化疗后,对照组患者T细胞亚群CD4^+,CD4^+/CD8^+较化疗前明显下降(P<0.05),且化疗后观察组患者CD4^+较对照组升高(P<0.05)。结论:大株红景天注射液联合紫杉醇^+顺铂方案治疗乳腺癌能改善患者细胞免疫水平。
Objective： To observe the effect and immunologic regulation of sofren injection in breast cancer patients,and investigate its action mechanism. Method： The 141 patients with breast cancer between June2013 to June 2015 were divided into observation group and control group by random number table. There were 69 cases in observetion group,including 9 drop-out cases,so only 60 cases completed this study. There were 72 cases in control group,including 10 drop-out cases,so only 62 cases completed this study. Both groups used paclitaxel and cisplatin chemotherapy program for 6 cycles,and patients in observation group also received sofren injection for10 days based on the chemotherapy. Cellular immunity indicators were observed in both groups,blood was collected on the mornings of 1 day before chemotherapy and 10 thday after chemotherapy to detect T cell subsets CD4^＋,CD8^＋,CD4^＋/CD8^＋values of two groups by flow cytometry before and after chemotherapy. Humoral immunity indicators： blood was collected on the mornings of 1 day early before chemotherapy and 10 thday after chemotherapy,the levels of immunoglobulin（ Ig） G,Ig A,Ig M,and complement C_3 were quantitatively determined by immunoturbidimetric assay. Drug toxicity reactions were observed in both groups： patients were observed for blood routine,liver and kidney functions during chemotherapy,and at the same time the drug toxicity reactions during chemotherapy were recorded by referring to WHO NCI-CTC3. 0 Criteria for Determination of Acute and Subacute Toxicity of Anticancer Drugs. After chemotherapy,the changes of T cell subsets,humoral immunity indicators and drug toxicities were compared between the two groups. Result： After one cycle of chemotherapy,the levels of CD4^＋,CD4^＋/CD8^＋in T cell subsets were decreased obviously in control group（ P〈0. 05）,and the level of CD4^＋in observation group was higher than that in control group after chemotherapy（ P〈0. 05）.Conclusion： Sofren injection combined with paclitaxel and cisplat
出处
《中国实验方剂学杂志》
CAS
CSCD
北大核心
2016年第21期172-176,共5页
Chinese Journal of Experimental Traditional Medical Formulae
基金
衡水市科技计划项目(14022A)
