摘要
目的：探讨促血管生成素-2（Ang-2）在胃癌组织中的表达情况及与患者的临床病理特征、远期预后的关系。方法：收集104例经石蜡固定的胃癌组织标本（胃癌组）、80例胃癌癌旁组织标本（癌旁组）、因胃部良性疾病行胃镜检查取正常胃黏膜的组织标本60例（对照组），分别采用免疫组织化学方法检测Ang-2蛋白的表达情况；同时分析Ang-2与患者的临床病理特征、远期预后的关系。结果：胃癌组患者的Ang-2阳性表达率72．12％，显著高于癌旁组的43．75％对照组的36．67％，差异均具有统计学意义（P〈0．05）。胃癌患者的Ang-2阳性表达情况与肿瘤的分化程度、浸润深度、TNM分期及发生淋巴结转移、远处转移有关（P〈0．05）；与患者的年龄、性别、肿瘤直径无关（P〉0．05）。随访60个月，Ang-2表达阳性的75例患者存活38例（50．67％），Ang-2表达阴性的29例患者存活侣例（62．07％），两组患者的5年存活率比较差异不具有统计学意义（X2=1．092，P=0．196）；Ang-2表达阴性的患者中位生存时间51个月，显著长于Ang-2表达阳性的患者（43个月，X2=3．984，P=0．037）。结论：Ang-2在胃癌组织中的表达显著高于正常组织，同时Ang-2阳性表达与胃癌的临床病理特征、预后有一定的关系。
Objective： To explore the relationships between the angiopoietin-2 （Ang-2） ex- pressionin gastric carcinoma tissue andciinical pathological characteristics and long-term prognosis of patients. Methods： 104 cases of paraffin embedded samples of gastric cancer tissue （gastric cancer group）, 80 cases of adjacent tissue samples of gastric cancer （adjacent group）, 60 cases of tissue samples from normal gastric mucosa by gastroscopy for benign diseases of the stomach （control group）were collected. Ang-2 proteins of the three groups were detected withimmunohis- tochemical method. The relationships between Ang-2 expression and clinical pathological character- istics and long-term prognosis of patients were analyzed. Results： The positive expression rate of Ang-2（72.12%） in gastric cancer group were higher than the adjacent group（43.75%） and the con- trol group（36.67%）. The differences were statistically significant （P〈0.05）. The positive expression of Ang-2 in gastric cancer was related to the degree of differentiation, depth of invasion, TNM stage and lymph node metastasis and distant metastasis（P〈0.05）. No relationship was observed between the positive expression of Ang-2 and the age of patient, sex and tumor diameter （P〉0.05）. During the 60 months follow-up, 38 cases （50.67%） were survived in 75 patients with positive Ang-2 ex- pression, while 18 cases （62.07%） were survived in 29 patients with negative Ang-2 expression. The difference of 5 year survival rate between the two groups was not statistically significant（ X2=1- 092, P=0.196）; The median survival time was 51 months in patients with negative expression of Ang-2, was longer than Ang-2 positive patients （43 months, X2=3.984, P=0.037）. Conclusion： The expression of Ang-2 in gastric carcinoma tissue is higher than the normal tissue. Besides the positive expression of Ang-2 is related to the clinical pathological characteristics and prognosis of gastric cancer.
出处
《中国现代普通外科进展》
CAS
2016年第9期703-706,710,共5页
Chinese Journal of Current Advances in General Surgery
关键词
促血管生成素-2
胃肿瘤
病理特征
远期预后
Angiopoietin-2
Stomach neoplasms
Pathological characteristics
Long-term prog- nosis
