摘要
目的探讨血清癌胚抗原(CEA)、糖类抗原19-9(CA19-9)、糖类抗原724(CA724)联合检测对胃癌的诊断价值。方法选择胃癌患者、胃部良性疾病患者和健康体检者,各40例,分别设为胃癌组、良性组和对照组。应用放射免疫分析法检测3组患者血清CEA、CA19-9、CA724水平。结果胃癌组血清CEA、CA19-9、CA724水平均显著高于良性组和对照组(P<0.01);胃癌组CEA、CA19-9、CA724联合检测阳性检出率显著高于任何一种标志物单独检测(P<0.05或P<0.01);联合检测的灵敏度高于血清CEA、CA19-9、CA724单独检测,差异有统计学意义(P<0.05或P<0.01)。结论血清CEA、CA19-9、CA724水平对于胃癌的诊断具有重要意义,联合检测可提高诊断灵敏度。
Objective To investigate the value of combined detection of serum carcinoembryonic antigen（ CEA）, carbohydrate antigen 19-9（ CA19-9） and carbohydrate antigen 724（ CA724） in diagnosis of gastric cancer. Methods Forty patients with gastric cancer,40 patients with benign gastric disease and 40 healthy people were respectively selected as gastric cancer group,benign group and control group. The levels of serum CEA,CA19-9 and CA724 in three groups were detected by radioimmunoassay. Results The levels of serum CEA,CA19-9 and CA724 in gastric cancer group were significantly higher than those in benign group and control group（ P〈0. 01）. The positive detection rate of combined detection of CEA,CA19-9 and CA724 was significantly higher than that of the single detection of any markers（ P〈0. 05 or P〈0. 01）. The sensitivity of combined detection was higher than that of single detection of serum CEA,CA19-9 and CA724,and there were significant differences（ P〈0. 05 or P〈0. 01）. Conclusion The levels of serum CEA,CA19-9 and CA724 are of great significance in the diagnosis of gastric cancer,and combined detection of these indexes can improve the diagnostic sensitivity.
出处
《实用临床医药杂志》
CAS
2016年第7期52-54,共3页
Journal of Clinical Medicine in Practice
关键词
胃癌
癌胚抗原
糖类抗原19-9
糖类抗原724
诊断价值
gastric cancer
carcinoembryonic antigen
carbohydrate antigen 19-9
carbohydrate antigen 724
diagnostic value
