摘要
目的探讨活血府逐瘀丸对慢性盆腔炎患者血清炎症因子及T淋巴细胞水平影响。方法收集奉化市人民医院妇科64例慢性盆腔炎患者,随机分为实验组和对照组,每组32例。对照组给予静脉头孢噻肟钠,实验组在对照组的基础上加以血府逐瘀丸加减口服,7 d为1个疗程,共治疗3个疗程。治疗结束后,比较治疗前后患者临床疗效、主要症状发生率、血清C反应蛋白(Creactionprotein,CRP)、白细胞介素-4(IL-4)、白细胞介素-10(IL-10)、肿瘤坏死因子-α(tumor necrosis factor,TNF-α)水平、外周血T淋巴细胞亚群以及不良反应发生情况。结果治疗后,与对照组相比实验组的总有效率较高(P<0.05)。2组主要症状发生率降低(P<0.05),血清CRP、TNF-α水平降低(P<0.05),血清IL-4以及IL-10水平升高(P<0.05),血清CD8^+水平降低(P<0.05),血清CD4^+、CD4^+/CD8^+水平升高(P<0.05);与对照组相比,实验组治疗后血清CRP、TNF-α较低(P<0.05),血清IL-4以及IL-10水平较高(P<0.05),盆腔积液发生率较低(P<0.05),血清CD8^+较低(P<0.05),血清CD4^+、CD4^+/CD8^+水平较高(P<0.05)。2组不良反应比较,差异无统计学意义。结论血府逐瘀丸对慢性盆腔炎临床疗效显著,推测其机制与降低血清CRP、TNF-α,升高IL-4以及IL-10水平,升高血清CD4^+、CD4^+/CD8^+水平有关。
Objective To investigate the effect of Xuefuzhuyu pill on serum inflammatory cytokines and T lymphocyte levels in patients with chronic pelvic inflammatory disease. Methods 64 cases of chronic pelvic inflammatory disease in our hospital were randomly divided into experimental group and control group,32 cases of each group. Control group received cefotaxime sodium 1. 0 g iv,metronidazole solution 200 m L iv,bid,experimental group were added with Xuefuzhuyu pill,1 pill bid. 7 days for a course and 2 groups were treated for 3 courese. Clinical efficacy,incidence of major symptoms,serum CRP,IL-4,IL-10,TNF-α,T lymphocyte subsets and adverse reactions occurred in peripheral blood were compared between two groups. Results After treatment,the total effective rate of the experiment group was higher than the control group（P〈0. 05）. After treatment,the main symptoms occurred of 2 groups decreased（P〈0. 05）,serum CRP,TNF-α levels decreased（P〈0. 05）,serum IL-4 and IL-10 levels increased（P〈0. 05）,serum levels of CD8＋decreased（P〈0. 05）,serum CD4＋,CD4＋/CD8＋levels increased（P〈0. 05）; compared with the control group,serum CRP,TNF-α in the experimental group were lower（P〈0. 05）,serum IL-4 and IL-10 levels were higher（P〈0. 05）,and pelvic effusion occurrence rate was lower（P〈0. 05）,CD8＋level was lower（P〈0. 05）,serum CD4＋,CD4＋/CD8＋were higher（P〈0. 05）. There was no significant difference in adverse reactions between the two groups. Conclusion Xuefuzhuyu pill in the treatment of chronic pelvic inflammatory disease is effective. It is speculated that the mechanism is related to the decrease of serum CRP,TNF-α,IL-4 and IL-10 levels,and the increase of serum CD4＋and CD4＋/CD8＋levels.
出处
《中国生化药物杂志》
CAS
2016年第7期148-150,共3页
Chinese Journal of Biochemical Pharmaceutics
