摘要
目的评价3种喹诺酮类药与阿莫西林对180株幽门螺杆菌（Hp）体外联合抗菌效应和临床根除率。方法采用二倍稀释法和棋盘格法，测定3种喹诺酮类药（环丙沙星、左氧氟沙星、莫西沙星）分别与阿莫西林单用及联用对180株Hp的最低抑菌浓度（MIC），计算其联合药敏指数（FIC值），并观察3种喹诺酮类药与奥美拉唑三联方根除Hp感染的疗效。结果3种喹诺酮类药与阿莫西林联用对Hp致病菌的MIC值均显著降低。环丙沙星FIC值：0．5～1为相加作用；左氧氟沙星FIC值0．5～0．75为相加作用，莫两沙星FIC值；0．09375～0．1875为协同作用。3种喹诺酮类药与奥美拉唑的三联方对Hp临床根除率分别为91．67％、73．33％和60．00％，P〈0．05。结论3种喹诺酮类药与阿莫西林联用对180株Hp抗菌作用增强以协同作用和相加作用为主，无拮抗效应，其Hp根除率排序莫西沙星〉左氧氟沙星〉环丙沙星。
Objective To valuate the antibiotic effects in vitro of 3 quinolones combined with Amoxillin against 180 Helieobacter pylori（Hp） strains and study the Hp eradication rate in our clinic. Methods With the method of agar dilution test and checkboard test, The MIC of ciprofloxacin and Amoxillin, Levofloxacin and Amoxillin, Moxifloxacin and Amoxillin alone or in combination against 180 strains Hp were detected and FIC index was calculated according to MIC values. The curative effect of 3 quinolones and omeprazole tripl therapy on eradication of Hp infection was observed. Results The MIC of 3 quinolones combined with Amoxillin against Hp was reduced significantly. FIC index of ciprofloxacin of 0.5 - 1.0 was additive action. FIC index of Levofloxacin of 0.5 - 0.75 was additive action. FIC index of Moxifloxacin of 0. 09375 - 0.1875 was synergism action. The Hp eradication rate of 3 quinalones and Omeprazole tripl therapy in our clinic was 91.67% ,73.33% and 60.00% , respectively （ P 〈 0.05）. Conclusion The antibiotic activity of 3 quinolones combined with Amoxillin against 1 80 Hp strains was enhanced significantly. Their effect was characterized by synergism and additive action instead of antagonistic effect. The Hp eradication rate was Moxifloxacin 〉 levofloxacin 〉 Ciprofioxacin.
出处
《医学研究杂志》
2010年第3期111-113,共3页
Journal of Medical Research
