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同型半胱氨酸水平对2型糖尿病患者冠心病严重程度影响的观察 被引量:2

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摘要 目的:观察不同同型半胱氨酸(Hcy)水平的2型糖尿病患者冠心病严重程度及心律失常发生情况。方法:选择确诊的2型糖尿病合并冠心病88例,根据血清Hcy水平分为Hcy重度升高组36例、Hcy轻度升高组23例和Hcy正常组29例。入组病例均行256排螺旋CT(MSCT)及24h动态心电图(DCG)检查,比较组间冠状动脉粥样硬化严重程度及心律失常的发生情况。结果:(1)Hcy重度升高组冠脉重度、中度狭窄比例显著或非常显著高于Hcy轻度升高组及Hcy正常组(P<0.05,P<0.01)。本组病例共检出冠脉中重度狭窄670个节段,其中,累及左冠状动脉前降支(LAD)共380个节段(56.7%),非常显著高于回旋支(LCX)、右冠状动脉(RCA)及其他部位(P<0.01);不同Hcy水平组间冠脉中重度狭窄累及部位差异不显著(P>0.05)。(2)Hcy重度升高组各类型心律失常发生率均显著或非常显著高于Hcy轻度升高组及Hcy正常组,其中,恶性心律失常(频发室性期前收缩、成对室性期前收缩、短阵室性心动过速)发生率非常显著高于Hcy轻度升高组及Hcy正常组(P<0.05,P<0.01)。结论:血清Hcy水平重度升高的2型糖尿病合并冠心病患者,其冠状动脉病变更严重,恶性心律失常的发生率显著增加。
出处 《人民军医》 2016年第6期579-581,共3页 People's Military Surgeon
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