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长链非编码RNA在自身免疫性疾病中的研究进展 被引量:3

Research progress of long noncoding RNAs in autoimmune diseases
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摘要 长链非编码RNA(LncRNAs)是转录本长度大于等于200 nt的,不具备编码蛋白功能的RNA。LncRNAs具有基因转录、蛋白质转运及染色质重塑等功能。LncRNAs参与多种免疫性疾病的发生、发展与转归,在自身免疫性疾病中发挥重要的作用。 Long noncoding RNAs( LncRNAs) are RNA transcripts larger than 200 nucleotides,which do not encode proteins. LncRNAs have diverse important properties,such as gene transcription,protein transport and chromatin remodeling,which involve in pathogenesis,development and prognosis of various immune diseases. The LncRNAs play crucial role in autoimmune diseases.
作者 邹利 王云甫
出处 《基础医学与临床》 CSCD 2016年第10期1441-1445,共5页 Basic and Clinical Medicine
基金 湖北省科技厅自然科学基金(2010CDB09103) 湖北省教育厅重点项目(D20112102) 2014年湖北医药学院优秀中青年科技创新团队资助计划项目(2014CXX01)
关键词 长链非编码RNA 自身免疫性疾病 系统性红斑狼疮 银屑病 多发性硬化 long noncoding RNAs autoimmune diseases systemic lupus erythematosus systemic sclerosis multiple sclerosis
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