摘要
Behcet病(Behcet's disease,BD)是一种累及多系统、由自身免疫介导的炎症性疾病,以非特异性血管炎为主要病理损害,其典型的临床特征包括口腔和生殖器溃疡、葡萄膜炎和皮肤病变等。BD的发病机制尚不明确,目前普遍认为BD的病因包括遗传学、表观遗传学、免疫学及环境因素等。表观遗传学是指DNA序列不发生变化而基因表达发生可遗传变化的机制,主要包括DNA甲基化、组蛋白修饰和非编码RNA等。多项研究证实,表观遗传学因素在BD发病机制中发挥重要作用。本文就BD的表观遗传学研究进展进行综述。
Behcet's disease(BD)is an autoimmune mediated inflammatory disease involving multiple systems with non-specific vasculitis as the main pathological damage.The typically clinical characteristics are recurrent oral ulcers,genital ulcers,uveitis and skin lesions.The aetiology of BD remains unclear.It is generally believed that multiple factors,including genetic,epigenetic,immunological and environmental factors,are involved in the pathogenesis of BD.Epigenetics refers to the mechanism that gene expression can change heritably without DNA sequence changes,including DNA methylation,histone modifications,and non-coding RNA.Several studies suggest that epigenetic factors play an important role in the pathogenesis of BD.This article reviews the advances of epigenetics in the pathogenesis of BD.
作者
郑光柄
王欣
于红松
Zheng Guangbing;Wang Xin;Yu Hongsong(School of Basic Medical Science,Special Key Laboratory of Ocular Diseases of Guizhou Province,Zunyi Medical University,Zunyi Guizhou 563099,China)
出处
《遵义医科大学学报》
2021年第2期255-259,264,共6页
Journal of Zunyi Medical University
基金
国家重点研发计划项目(NO:2018YFC1004303)
国家自然科学基金面上项目(NO:81670844)
贵州省科学基金重点项目(NO:黔科合基础[2019]1464)
贵州省普通高等学校科技拔尖人才支持计划项目(NO:黔教合KY字[2017]077)
遵义医科大学优秀青年人才计划(NO:18-ZY-001)。
