摘要
目的探讨乙型肝炎肝硬化伴上消化道出血患者发生医院感染的相关因素,为乙型肝炎肝硬化伴上消化道出血患者预防医院感染提供理论依据。方法选取2013年2月-2015年2月在医院接受治疗的288例乙型肝炎肝硬化伴上消化道出血患者作为研究对象,对患者医院感染的病原菌分布和感染部位进行统计,采用SPSS19.0软件进分析患者医院感染的相关因素。结果 288例乙型肝炎肝硬化伴上消化道出血患者中,发生医院感染84例,感染率29.17%;84例医院感染的患者中,感染部位标本培养检出38株病原菌,其中革兰阴性菌20株,占52.63%;革兰阳性菌11株,占28.95%;真菌7株,占18.42%;感染部位以腹腔感染为主,占30.95%;相关因素分析显示:年龄、预防性使用抗菌药物、腹水、三腔两囊管压迫止血、胃镜套扎止血等是乙型肝炎肝硬化伴上消化道出血患者发生医院感染的高危因素(P<0.05)。结论乙型肝炎肝硬化伴上消化道出血患者应积极应用抗菌药物进行预防感染治疗,加强疾病发展各阶段的对症治疗,以降低医院感染率。
OBJECTIVE To explore the related factors for nosocomial infections in hepatitis B cirrhosis patients complicated with upper gastrointestinal bleeding so as to provide theoretical basis for prevention of nosocomial infections in the hepatitis B cirrhosis patients complicated with upper gastrointestinal bleeding.METHODS A total of288 hepatitis B cirrhosis patients complicated with upper gastrointestinal bleeding who were treated in the hospital from Feb 2013 to Feb 2015 were recruited as the study objects,then the distribution of pathogens causing the nosocomial infections and infection sites were statistically analyzed,and the related factors for the nosocomial infections were analyzed by using SPSS19.0software.RESULTS Of the 288 hepatitis B cirrhosis patients complicated with upper gastrointestinal bleeding,84 had nosocomial infections,with the infection rate 29.17%.Totally 38 strains of pathogens were isolated from the infection site specimens that were obtained from the 84 patients with nosocomial infections,including 20（52.63%）strains of gram-negative bacteria,11（28.95%）strains of grampositive bacteria,and 7（18.42%）strains of fungi.The patients with abdominal infections accounted for 30.95%among the patients with nosocomial infections.The analysis of the related factors indicated that the high risk factors for the nosocomial infections in the hepatitis B cirrhosis patients complicated with upper gastrointestinal bleeding included the age,prophylactic use of antibiotics,ascites,two three-lumen balloon catheter hemostasis,and endoscopic ligation of bleeding（P〈0.05）.CONCLUSIONIt is necessary for the hepatitis B cirrhosis patients complicated with upper gastrointestinal bleeding to actively use antibiotics for prevention of the infections and strengthen the symptomatic treatment of diseases in various development stages so as to reduce the incidence of the nosocomial infections.
出处
《中华医院感染学杂志》
CAS
CSCD
北大核心
2016年第17期3903-3905,共3页
Chinese Journal of Nosocomiology
基金
山东省自然科学基金资助项目(2014077)
关键词
乙型肝炎
肝硬化
上消化道出血
医院感染
相关因素
Hepatitis B
Cirrhosis
Upper gastrointestinal bleeding
Nosocomial infection
Related factor
