摘要
目的分析D-二聚体(DD)和纤维蛋白原(FDP)与复发性多软骨炎(relapsing polychondritis,RPC)的疾病活动及其和呼吸道受累的关系。方法回顾性分析2010年1月至2015年12月在郑州大学第一附属医院确诊的52例RPC的住院患者DD和FDP结果,并比较呼吸道受累和未受累患者DD和FDP结果的差异。结果 52例RPC患者中喉、气管、支气管软骨炎等呼吸道受累29例(55.8%),DD和FDP两者或者两者之一升高的患者37例(71.2%),血清DD与血沉(ESR)呈正相关(r=0.635,P=0.000);与C反应蛋白(CRP)呈正相关(r=0.421,P=0.002)。血清FDP与ESR呈正相关(r=0.725,P=0.000);与CRP呈正相关(r=0.689,P=0.000)。RPC患者呼吸道受累与未出现呼吸道损害之间DD差异具有统计学意义(P<0.01),FDP差异无统计学意义(P=0.146)。结论呼吸道受累在RPC中并不少见,而且是影响RPC预后的重要因素。DD和FDP检测对于判断RPC疾病活动具有重要意义,DD和FDP升高和呼吸道受累具有重要关系,可以和ESR、CRP等炎症指标一起作为疾病活动或者严重性的指标。
Objective To analyze the clinical significance of D-dimer（DD）and fibrinogen（FDP）in relapsing polychondritis（RPC）and respiratory tract involvement.Methods A retrospective analysis of DD and FDP was performed in 52 cases of confirmed RPC patients hospitalized in the First Affiliated Hospital of Zhengzhou University in January 2010-December 2015.And the difference of DD and FDP levels of respiratory tract involvement and noninvolvement patients were compared.Results 29cases（55.8%）in 52 RPC patients were with laryngeal and tracheal,bronchial cartilage inflammation of respiratory tract.37cases（71.2%）with higher level DD,FDP or both.Serum DD and blood sedimentation were positively correlated（r=0.635,P =0.000）.And the CRP positive correlation（r=0.421,P =0.002）.Serum FDP positively related to the blood sedimentation（r=0.725,P =0.000）;And CRP（r=0.689,P =0.000）.The DD differences between patients with respiratory tract involvement and non involvement appeared statistically significant（P〈0.001）,the difference of FDP had no statistical significance（P =0.146）.Conclusion Respiratory tract involvement is not uncommon in RPC,and it is the most important factor influencing the prognosis of RPC.DD and FDP detection are of great significance for determining RPC disease activity,DD and elevated FDP and respiratory tract involvement have important relation,with ESR and CRP,these inflammation markers can be the indexes of disease activity or severity.
出处
《临床荟萃》
CAS
2016年第9期1011-1014,共4页
Clinical Focus
