摘要
目的探讨原发性高血压病(EH)患者血清瘦素(LP)、可溶性瘦素受体(SLR)及沉默信息调节因子相关酶3(SIRT3)水平与动脉粥样硬化(AS)之间的关系。方法选取2015年7月—2016年1月在桂林医学院附属医院心血管内科及特需病区住院的EH患者60例为EH组,及同期在本院进行体检的健康成年人60例为对照组。根据高血压分级将EH组患者分为高血压1、2、3级,各20例。根据颈动脉内膜-中层厚度(cIMT)将所有受试者分为cIMT正常组55例、cIMT增厚组52例和颈动脉斑块形成组13例。采用ELISA检测所有受试者血清LP、SLR及SIRT3水平,以cIMT来评估AS程度,同时检测空腹血糖(FPG)、总胆固醇(TC)、三酰甘油(TG)、高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇(LDL-C)、尿素氮(BUN)、肌酐(Cr)等相关指标。结果 EH组患者血清LP、SIRT3水平及cIMT均高于对照组,血清SLR水平低于对照组,差异有统计学意义(P<0.05)。不同高血压分级患者血清LP、SLR、SIRT3水平及cIMT间差异均有统计学意义(P<0.05),其中高血压3级患者血清LP、SIRT3水平及cIMT高于高血压1、2级患者,血清SLR水平低于高血压1、2级患者;高血压2级患者血清LP、SIRT3水平高于高血压1级患者,血清SLR水平低于高血压1级患者。不同cIMT分组患者血清LP、SLR、SIRT3水平间差异均有统计学意义(P<0.05),其中颈动脉斑块形成组患者血清LP、SIRT3水平高于cIMT正常组、增厚组,血清SLR水平低于cIMT正常组、增厚组;cIMT增厚组患者血清LP、SIRT3水平高于cIMT正常组,血清SLR水平低于cIMT正常组。cIMT与LP、SIRT3呈直线正相关(r值分别为0.725、0.683,P<0.05),与SLR呈直线负相关(r=-0.720,P<0.05)。多元Logistic回归分析结果显示,LP、SIRT3是cIMT增厚的独立危险因素(P<0.05),而SLR是cIMT增厚的独立保护因素(P<0.05)。结论血清LP、SLR、SIRT3水平与高血压及cIMT密切相关,说明瘦素抵抗、SIRT3可能参与了EH及AS的形成和发�
Objective To analyze the relationship between serum leptin（ LP）,soluble leptin receptor（ SLR） and silent information regulator factor related enzyme 3（ SIRT3） with atherosclerosis（ AS） in patients with essential hypertension（ EH）. Methods 60 cases with EH,who were hospitalized in Cardiovascular Department of Internal Medicine and VIP Ward of the Affiliated Hospital of Guilin Medical College from July 2015 to January 2016,were selected as the EH group,and 60 cases of healthy adults examined medically during the corresponding period in our hospital were selected as the control group. The 60 cases with EH were divided into the patients with hypertension stage 1,stage 2 and stage 3 according the hypertension grading,with each stage 20 cases respectively. All subjects were divided in accordance with carotid intima media thickness（ cIMT） into cIMT normal group with 55 cases,cIMT thickness group with 52 cases and the plaque formation group with 13 cases. Serum LP,SLR and SIRT3 levels were tested by ELISA method,and cIMT was used to measure the degrees of AS and to examine the relative indicators of fasting plasma glucose（ FPG）,total cholesterol（ TC）,triacylglycerol（ TG）,high density lipoprotein cholesterol（ HDL-C）,low density lipoprotein cholesterol（ LDL-C）,blood urea nitrogen（ BUN） and creatinine（ Cr）,etc. Results The cIMT and serum LP,SIRT3 levels of EH group were significantly higher than those of the control group,while serum SLR level of the EH group was significantly lower than that of control group, and differences were statistically significant（ P〈0. 05）.Differences among cIMT and serum LP,SIRT3 levels of the patients with different hypertension grades were statistically significant（ P〈0. 05）. Among them,cIMT and serum LP,SIRT3 levels of the patients with hypertension stage 3 were significantly higher than that of patients with hypertension stage 1 and 2,while serum SLR level was lower than that of patients with hypertension stage 1 and 2; cIMT and
出处
《中国全科医学》
CAS
CSCD
北大核心
2016年第22期2676-2680,共5页
Chinese General Practice
基金
广西科学研究与技术开发计划项目(桂科能1598025-29)
广西医疗卫生适宜技术研究与开发课题(S201316-03)
关键词
瘦素
受体
瘦素
沉默信息调节因子相关酶3
高血压
动脉粥样硬化
Leptin
Receptors
leptin
Silent information regulator factor related enzyme 3
Hypertension
Atherosclerosis
