摘要
目的研究莛子藨Triosteum pinnatifidum地上部分的化学成分。方法利用硅胶、Sephadex LH-20、反相ODS等柱色谱技术进行分离和纯化,综合运用质谱、核磁共振波谱方法鉴定化合物结构。结果从莛子藨地上部分乙醇提取物中分离得到10个化合物,包括2个单萜二糖苷:(E)-(6S)-8-[α-L-arabinopyranosyl-(1→6)-β-D-glucopyranosyloxy]-2,6-dimethyloct-2-eno-1,3"-lactone(1)、urceolide(2)和8个酚类化合物:2,3-二氢穗花杉双黄酮(3)、芹菜素4'-O-β-D-葡萄糖苷(4)、芹菜素7-O-β-D-葡萄糖苷(5)、原儿茶酸(6)、没食子酸乙酯(7)、tachioside(8)、icariside F2(9)、icariside E4(10)。结论除化合物2外,其他化合物均为首次从本属植物中分离得到。化合物1结构中的阿拉伯糖应更正为~1C_4式的α-L-阿拉伯糖。
Objective To study the chemical constituents in the aerial parts of Triosteum pinnatifidum. Methods The constituents were isolated and purified by silica gel, Sephadex LH-20, and ODS column chromatography. Their structures were elucidated by spectroscopic methods including 1D and 2D NMR experiments and HR-ESI-MS analyses. Results Ten compounds were isolated from the aerial parts of T. pinnatifidum, among them there were two monoterpene diglycosides and eight phenols. They were identified as （E）-（6S）-8- [ct-L-arabinopyranosyl-（1--~6）-^-D-glucopyranosyloxy] -2,6-dimethyloct-2-eno- 1,3 ＂-lactone （1）, urceolide （2）, 2,3-dihydroamentoflavone （3）, apigenin-4＇-O-[3-D-glucoside （4）, apigenin-7-O-~3-D-glucoside （5）, protocatechuic acid （6）, ethyl gallate （7）, tachioside （8）, icariside F2 （9）, and icariside E4 （10）. Conclusion All the compounds except compound 2 are isolated from the plants of Triosteum Linn. for the first time. The arabinopyranosyl moiety of compound 1 is revised as ^1C4 β-L-arabinopyranose.
出处
《中草药》
CAS
CSCD
北大核心
2016年第12期2089-2094,共6页
Chinese Traditional and Herbal Drugs
基金
教育部新世纪优秀人才支持计划资助项目(NCET-09-0589)
