摘要
近年来越来越多证据表明内皮间质转分化(endothelial-to-mesenchymal transition,End MT)不但在心血管系统的发育过程中发挥着关键作用,在各种心血管疾病(cardiovascular disease,CVD)发生中也扮演着重要角色。文中主要综述EndMT参与CVD发生发展过程的常见信号机制,并讨论如何在这些信号通路网找到逆转End MT的线索,为防治CVD提供新的靶点。
Recent studies have demonstrated that endothelial-to-mesenchymal transition （EndMT） plays a pivotal role in the cardiovascular system, spanning cardiovascular development through to cardiovascular diseases （CVD）. In this review, we describe the common signaling mechanisms that promote EndMT participating in the pathological process of CVD, and we discuss how these in- tracellular cascades participate in crosstalk to integrate cues to reverse EndMT, which potentially may provide novel therapeutic oppor- tunities for CVD.
出处
《医学研究生学报》
CAS
北大核心
2016年第8期872-876,共5页
Journal of Medical Postgraduates
基金
国家自然科学基金(81460046)
江西省自然科学基金(20142BAB205040)
关键词
内皮间质转分化
心血管疾病
信号通路
内皮细胞
Endothelial-to-mesenchymal transition
Cardiovascular disease
Signal pathway
Endothelial cell
