摘要
目的观察川芎嗪注射液对新生儿硬肿症(SN)患儿血胱抑素C(Cys C)的影响。方法 69例SN患儿为SN组,30名新生儿为对照组。SN患儿中轻度患儿39例,中重度患儿30例。轻度、中重度患儿采用随机数字表法分为治疗组与常规组,常规组采用常规支持疗法和对症处理,治疗组在常规组治疗基础上加用川芎嗪注射液6mg/kg(加入5%葡萄糖注射液30mL静脉滴注),每日1次,均治疗7日。检测血Cys C与BUN、Cr水平,计算Cys C与BUN、Cr异常率,并进行相关关系分析。同时观察各组患儿硬肿消退时间。结果与对照组比较,SN组治疗前血Cys C明显升高(t=10.55,P<0.01),而BUN、Cr与对照组比较,差异无统计学意义(t=1.50,1.73;P>0.05);与轻度患儿比较,中重度患儿血Cys C明显升高(t=2.11,P<0.05),BUN、Cr虽有增高趋势,但差异无统计学意义(t=2.07,1.92;P>0.05)。经直线相关分析,SN组血清Cys C与BUN、Cr分别存在正相关关系(r=0.314,0.287;P<0.05)。SN患儿Cys C、BUN、Cr的异常率为72.5%(50/69)、27.5%(19/69)及36.2%(25/69),Cys C的异常率显著高于BUN、Cr(χ2=41.04,P<0.01)。治疗后,与常规组比较,SN轻度、中重度患儿治疗组血Cys C水平及硬肿消退时间明显下降(P<0.05),BUN、Cr则差异无统计学意义(P>0.05)。结论血Cys C可早期反映SN患儿肾功能损害,而川芎嗪注射液可以明显降低血Cys C水平,促进硬肿症新生儿肾损害的恢复,缩短硬肿消退时间。
Objective To observe the effects of Ligustrazine Injection （LI） on serum cystatin C （Cys C） level in sclerema neonatorum /SN） children patients. Methods Totally 69 SN children patients were recruited as the SN group, 39 with mild SN and 30 with moderate-severe SN. Another 30 neonates were recruited as a control group. Mild SN children patients and moderate-severe SN children patients were respectively assigned to the treatment group and the routine group according to random digit table. Children patients in the routine group received routine supportive treatment and symptomatic treatment, while those in the treatment group were additionally injected with LI i6 mg/kg, adding in 30 mL 5% glucose injection; once per day）. All treatment lasted for 7 successive days. Serum level of Cys C, blood urea nitrogen （BUN）, and creatinine /Cr） were detected. The abnormality rate of Cys C, BUN, and Cr was respectively calculated, and their correlations analyzed. Meanwhile, scleroma subsidence time was observed in each group. Results The serum level of Cys C was obviously elevated more in the SN group than in the control group （t =10.55, P 〈0.01 ）. There was no statistical difference in serum level of BUN or Cr between the control group and the SN group （t = 1.50, 1.73; P 〉0.05）. Serum Cys C level obviously increased in moderate-severe SN children patients than in mild SN children patients it =2.11, P 〈0.05）; serum levels of BUN and Cr showed increasing tendency in moderate-severe SN children patients and mild SN children patients, but with no statistical difference（t =2.07, 1.92 P 〉0. 05）. Linear correlation showed that serum Cys C level was respectively positively correlated with serum BUN level and serum Cr level in the SN group （r =0. 314,0. 287,P 〈0. 05）. The abnormality rate of serum Cys C, BUN, and Cr was 72.5% （50/69）, 27.5% （19/69）, and 36.2% （25/69）, respectively. The abnormality rate of serum Cys C was significantly higher than that of BUN or Cr （X2 =41.04; P
出处
《中国中西医结合杂志》
CAS
CSCD
北大核心
2016年第8期908-911,共4页
Chinese Journal of Integrated Traditional and Western Medicine
基金
国家自然科学基金资助项目(No.11471152)
