摘要
目的 探析骨桥蛋白（OPN）在子痫前期患者胎盘组织中的表达及作用。方法 选择我院产科2013年1月-2014年12月收治75例子痫前期住院分娩产妇及75例健康产妇进行研究,将其作为研究组和对照组,研究组30例为轻度PE（轻度组）、45例为重度PE（重度组）,用免疫组织化学方法检测两组胎盘组织中OPN表达情况并比较。结果研究组和对照组均存在明显OPN表达,以胎盘绒毛滋养细胞胞膜、胞质以及胎盘毛细血管内皮细胞为主要表达部位;在OPN免疫反应产物吸光度方面,重度组OPN免疫反应产物吸光度最低,对照组最高,三组间两两比较均有统计学意义（P〈0.05）。结论 OPN参与子痫前期发病,且在子痫前期患者胎盘组织中表达明显减弱,但到底是PE病因还是疾病结果有待深入研究。
Objective To study the expression and function of osteopontin （OPN） in placenta tissue of patients with preeclampsia. Methods 75 cases of pregnant women with preeclampsia admitted into our hospital from January 2013 to December 2014 and 75 healthy women were selected as the research object, as the study group and the control group, 30 cases in the study group were mild PE （mild group）, 45 cases were severe PE （severe group）. The expression of OPN in placenta tissue of the two groups was detected and compared by immunohistochemical method. Results There were obvious expression of OPN of the two groups and the cell membrane of placental trophoblast cells, cytoplasm and placental capillary endothelial cells were the mainly expressing parts. From the aspect of absorbtivity of immune response of OPN, the absorbtivity of OPN immune reaction product of the severe group was the lowest while the control group was highest. The contrast differences among the three groups were statistically significant （P〈0.05）. Conclusion OPN is involved in the pathogenesis of preeclampsia, and its expression in placenta of patients with preeclampsia decreases significantly, but further study is needed to confirm whether the results are caused by PE or disease.
出处
《中国继续医学教育》
2016年第18期35-36,共2页
China Continuing Medical Education
关键词
OPN
子痫前期
胎盘组织
表达
OPN
OPN
Preeclampsia
Placenta tissue
Expression
