摘要
目的探讨文拉法辛联合小剂量米氮平和阿立哌唑治疗老年抑郁伴失眠和焦虑患者的疗效。方法 56例老年抑郁症患者均给予文拉法辛联合小剂量米氮平和阿立哌唑治疗,采用汉密尔顿抑郁量表(HAMD)和汉密尔顿焦虑量表(HAMA)分别在治疗前和治疗2、4、8周后评定疗效。结果患者经治疗均取得了较好效果,治疗2、4、8周后HAMD和HAMA减分显著,均低于治疗前(P<0.01)。结论文拉法辛与小剂量米氮平及阿立哌唑联合用药可快速改善老年抑郁伴失眠和焦虑患者的临床症状,提高患者服药的依从性和战胜疾病的信心,降低了苯二氮类药物使用量,且不良反应无明显增加。
Objective To investigate curative effect by venlafaxine combined with small dose of mirtazapine and aripiprazole in the treatment of senile depression complicated with insomnia and anxiety patients. Methods There were 56 senile depression patients, who received venlafaxine combined with small dose of mirtazapine and aripiprazole for treatment, receiving Hamilton depression scale（HAMD） and Hamilton anxiety scale（HAMA） for curative effect evaluation before and in 2, 4, 8 weeks after treatment. Results All patients had precise effect in treatment, and their HAMD and HAMA scores were all lower in 2, 4, 8 weeks after treatment than those before treatment（P〈0.01）. Conclusion Combined drug therapy by venlafaxine combined with small dose of mirtazapine and aripiprazole can quickly improve clinical symptoms of senile depression complicated with insomnia and anxiety patients, along with compliance and confidence, and reduce applied dose of benzodiazepine, without any increased adverse reactions.
出处
《中国实用医药》
2016年第17期50-51,共2页
China Practical Medicine
