摘要
目的探讨丙型病毒性肝炎（丙肝）患者配偶感染HCV风险及其影响因素。方法选取重庆市南川区各医疗机构诊断的性活跃慢性丙肝患者96例及其配偶为研究组,性别、年龄匹配的因其他疾病入院患者（HCV筛查阴性）96例及其配偶为对照组,采集患者血清、配偶体液样本,检测患者体液带毒情况及配偶血清感染情况,并进行问卷调查。结果研究组96例患者体液抗-HCV/HCV RNA阳性人数23（23.96%）/40（41.67%）,高于对照组（P0.05）;研究组96例患者配偶或性伴血清抗-HCV/HCV RNA阳性人数22（22.92%）/27（28.12%）,高于对照组（P〈0.05）,不同性别阳性率差异无统计学意义（P〈0.05）。logistic回归分析模型结果显示,低安全套使用频率（OR=0.483,95%CI=0.280-0.736）、结婚年限长（OR=1.838,95%CI=1.177-3.980）是配偶阳性的独立危险因素。结论慢性丙肝患者配偶感染风险较高,患者体液带毒率较高,安全套使用、结婚年限是感染的影响因素,配偶感染可能与性传播有关。
Objective To study the risk and influencing factors of HCV infection among spouses of sexually active patients with chronic hepatitis C（CHC）. Methods Ninety-six sexually active patients with CHC and their spouses were enrolled into the study,another 96non-CHC inpatients and their spouses were served as controls（age and gender matched）.Blood samples,seminal fluid and vaginal discharges were collected from patients and their spouses to detect anti-HCV and HCV-RNA.A questionnaire survey was also conducted.Results The positive rates of anti-HCV and HCV-RNA were 23.96% and 41.67% among CHC patients and22.92% and 28.12% among their spouses,which were all higher than that in controls（P〈0.05）,and were similar between males and females（P〉0.05）.Logistic aggression analysis showed that lower condom-use frequency（OR=0.483,95%CI：0.280-0.736）and more years in marriage（OR=1.838,95%CI：1.177-3.980）were independent risk factors of HCV infection among spouses of CHC patients. Conclusions Spouses of sexually active CHC patients are at high risk of HCV infection due to the high positive rate of HCV in their seminal fluid which might be transmitted by sexual intercourse.Condom use and marriage years are found to be influencing factors of HCV infection.
出处
《中国预防医学杂志》
CAS
2016年第7期518-520,共3页
Chinese Preventive Medicine
基金
重庆市教育科学"十一五"规划高校重点课题资助项目(2010-GJ-0411)
重庆市沙坪坝区科学委员会资助项目(201203)
