摘要
目的探讨小红细胞百分比(%Micro)与低色素红细胞百分比(%Hypo)的比值对常见3种珠蛋白生成障碍性贫血(地贫)和缺铁性贫血(IDA)的诊断价值。方法选择49例IDA患者、24例轻型α地贫患者、24例轻型β地贫患者、24例静止型α地贫患者、120例健康体检者作为研究对象,将其分为6组:健康组、IDA组、轻型α地贫组、轻型β地贫组、静止型α地贫组、轻型地贫组(为轻型α地贫组和轻型β地贫组的合并组)。分别检测各组%Micro和%Hypo并计算出两者比值,对结果进行分析比较。结果轻型地贫组与IDA组之间,轻型地贫组、IDA组分别与健康组之间,%Micro/%Hypo比较差异均有统计学意义(P<0.01)。静止型α地贫组与健康组之间,轻型α地贫组与轻型β地贫组之间,%Micro/%Hypo比较差异均无统计学意义(P>0.05)。以0.9作为%Micro/%Hypo鉴别诊断轻型地贫和IDA的判别值,则其诊断轻型地贫的敏感度、特异度、准确度分别为91.67%、91.89%、91.72%,诊断IDA的敏感度、特异度、准确度分别为91.94%、91.25%、91.18%。结论 %Micro/%Hypo对轻型α地贫、轻型β地贫、IDA有较好的鉴别诊断和辅助筛查价值,对静止型α地贫的临床价值不大。
Objective To investigate the diagnostic value of the ratio of%Micro to %Hypo in the diagnosis of three kinds of common thalassemia and iron-deficiency anemia（IDA）.Methods Forty-nine cases of IDA,24 cases of mildα-thalassemia,24 cases of mildβ-thalassemia,24 cases of silentα-thalassemia and 120 individuals undergoing healthy physical examination were selected as the research subjects and divided into 6groups：normal group,IDA group,mildα-thalassemia group,mildβ-thalassemia group,silentα-thalassemia and mild thalassemia group（in duding mildα-thalassemia group and mildβ-thalassemia group）.The%Micro and %Hypo were deteced in each group and their ratio was calculated.The results were performed the analysis and comparison.ResultsThe%Micro/%Hypo ratio had statistical difference between the mild thalassemia group and IDA group,between the mild thalassemia and IDA group with the normal group（P〈0.01）.The%Micro/%Hypo ratio had no statistical difference between the silentα-thalassemia group and normal group,and between the mildα-thalassemia group and mildβ-thalassemia group（P〈0.05）.With the%Micro/%Hypo ratio of 0.9as the discriminant value to diagnose mild thalassemia and IDA,its sensitivity,specificity and accuracy for diagnosing mild thalassemia were 91.67%,91.89% and 91.72%respectively,the sensitivity,specificity and accuracy in diagnosing IDA were 91.94%,91.25%and 91.18%respectively.Conclusion The ratio of%Micro/%Hypo has good differential diagnosis and assisted diagnosis screening value,but has little value for diagnosing silentα-thalassemia.
出处
《国际检验医学杂志》
CAS
2016年第14期1918-1919,1922,共3页
International Journal of Laboratory Medicine
基金
广东省佛山市卫生局医学科研课题项目(2014322)
