摘要
背景:细胞生长因子参与了多种细胞过程的调节,对伤口愈合和组织再生中起重要的调控作用。目的:阐述细胞生长因子与骨骼肌损伤修复等一系列细胞行为,旨在为骨骼肌损伤后积极的治疗、合理的康复以及合成生长因子生物材料提供帮助和借鉴。方法:以"Skeletal muscle,Damage repair,Insulin-like growth factor,Epidermal growth factor,growth factor"为关键词在PubM ed、Mendeley、Google学术搜索和CKNI电子数据库进行检索,检索范围为1995年到2015年11月的相关研究文献,并对文献进行筛选、归类、梳理和总结。结果与结论:根据纳入标准,确定了51篇文章作为标准文献。运动可导致骨骼细胞肌损伤后的修复和再生,会激活肌膜和基底膜的卫星细胞,产生大量成肌细胞,修补受损的肌纤维或再生形成新的肌纤维来恢复功能。这一过程伴随着复杂的生物学调节机制,与大量的细胞生长因子相关。外源性生长因子可以促进内源性生长因子的mR NA表达,刺激成肌细胞的增殖,加速肌管融合成肌纤维,修复骨骼肌的创伤,此过程也抑制了瘢痕组织的形成,从而改善了骨骼肌的愈合质量。
BACKGROUND：Growth factors involved in the regulation of cel ular processes play an important role in the wound healing and tissue regeneration. OBJECTIVE：To elaborate the role of a variety of cel ular processes involving growth factors in the repair of skeletal muscle injury, and to provide the references for the treatment and rehabilitation strategies, and the synthesis of biomaterials with growth factor for the skeletal muscle after injury. METHODS：A computer-based online search was conducted in PubMed, Mendeley, Google Scholar, and CNKI databases from 1995 to November 2015 to screen the relevant literatures using the keywords“skeletal muscle, damage repair, insulin-like growth factor, epidermal growth factor, growth factor”. Data screening, processing, and summary were performed. RESULTS AND CONCLUSION：Fifty-one eligible literatures were included. Exercise training promotes the repair and regeneration of the injured skeletal muscle cel s and the recovery of the function by activating satel ite cel s in the sarcolemma and basement membrane to produce the numerous myoblasts. The repair involves the complex biological process regulated by growth factors. Exogenous growth factors up-regulate the mRNA expression of endogenous growth factors, stimulate the proliferation of the myoblasts, accelerate the fusion between myotubes and muscle fibers, promote the repair of skeletal muscle injury, inhibit the formation of scars, thereby enhancing the healing quality.
出处
《中国组织工程研究》
CAS
北大核心
2016年第29期4402-4408,共7页
Chinese Journal of Tissue Engineering Research
