摘要
目的:观察疏血通注射液预防血管吻合口血栓形成的临床疗效。方法:将2013年1月-2015年3月就诊的77例断指再植患者随机分为S组(实验组)39例48指和D组(对照组)38例42指。S组术后给予疏血通治疗,D组术后给予低分子右旋糖酐对照治疗,其余常规治疗两组相同。术后做凝血功能实验室检查,用药后30min、1d、3d、7d四个时间点抽血检测人血栓素B2等指标。结果:两组患者再植指体存活率、毛细血管充盈时间比较,差异无统计学意义,P>0.05。两组术后指体肿胀程度比较,S组优于D组,差异有统计学意义,P<0.05。两组毛细血管危象发生率比较,S组低于D组。两组术后1d、3d及7d PT、APTT检测比较,S组与D组相当,差异无统计学意义,P>0.05。ELISA检测结果比较,治疗后S组血液人血栓素B2、前列腺素F1α、P选择素、丙二醛和人超氧化物歧化酶(SOD)含量下降。D组人血栓素B2、丙二醛下降明显,人6-酮-前列腺素F1α上升,其余指标稍有波动,但两组间各项指标均无统计学差异,总体上S组与D组相当。总体疗效比较,S组优于D组,P=0.049,差异有统计学意义。结论:疏血通注射液配合基础治疗与低分子右旋糖酐注射液配合基础治疗在防治断指再植术后患者疗效方面比较,疏血通注射液有减轻再植指体术后肿胀程度、提高指体存活率的作用,但在改善患者术后凝血指标上没有明显优势。
Objective： To evaluate effects of the Shuxuetong injection on preventing from the thrombus formation of vascular anastomotic site. Methods： 77 cases were divided randomly into the treatment group （S group,n=39） and control group （D group,n=38）. The treatment group was treated with the Shuxuetong injection, and the control group was given rheomacrodexother. Coagulation function, thromboxane B2 at 30min, 1 day, 3 day, 7day were recorded and observed. Results： There was no difference of survival rate and capillaries condition （P〉0.05）. The swelling extent was better in the S group （P〈0.05）. Circulation crisis was better in the S group. The difference between groups was similar in PT and APTT test in 1 day, 3 day, 7 day （P〈0.05）.The ELISA test shows that thromboxaneB2, prostaglandin F1α, P-selection, malonyldialdehyde and SOD in the D group were more decreasea. Thromboxane B2 and malonyldialdehyde were more decrease, while 6-keto-PGF1αwere increased in the D group. The total effcacy was better in the S group,P=0.049; there is a statistically signiifcant difference between them. Conclusion： The Shuxuetong injection can alleviate the swelling of replantation, improve survival rate of ifnger and promote the recovery of ifnger function.
出处
《中医临床研究》
2016年第17期12-15,共4页
Clinical Journal Of Chinese Medicine
关键词
疏血通注射液
血栓形成
临床观察
The Shuxuetong injection
Thrombosis
Clinical observation
