摘要
人副流感病毒（human parainfluenza virus, HPIV）是常见的社区获得性呼吸道感染病原，各亚型临床流行病学及临床特征各有特点。HPIV亦可引起呼吸系统外的其他系统损害。相同型别HPIV间核苷酸及氨基酸序列具有高度同源性，但仍存在部分基因突变以及氨基酸变异，多数研究表明其系统进化存在时间、地域差异。血球凝集素一神经氨酶蛋白（hemagglutinin-neuraminidase, HN）是HPIV蛋白中最具多态性的蛋白。HN蛋白活性部位的某些氨基酸变异会影响其活性，许多基因易突变区引起氨基酸变异对HN蛋白活性的影响目前尚未确定。深入了解HPIV的流行特点、临床特征、系统进化情况对该病毒流行的防控具有重要的意义。
Human parainfluenza virus（HPIV） is one of the most common pathogens of community acquired respiratory infection. The epidemiology and clinical features vary in different subtypes. HPIV also affect other systems except respiratory system. The sequences of nucleotide and amino acid showed high identity among the strains in the same type, while remaining some variation. Most research shows the variation associated with time and district. Hemagglutinin-neuraminidase（HN） protein shows most polymorphic among all the proteins of HPIV. Some amino acid variation among the active site of HN protein will affect its activity. The influence of many gene mutations, which lead to amino acid variation, and affect the activity of HN protein remains uncertain. Further study on the epidemiology, clinical features, phylogenetics analysis of HPIV plays an important role in the prevention and control of its prevalence.
出处
《国际儿科学杂志》
2016年第6期466-469,共4页
International Journal of Pediatrics
基金
浙江省科技厅项目（2015C37026）
关键词
人副流感病毒
流行病学
临床特征
系统进化
Human parainfluenza virus
Epidemiology
Clinical features
Phylogenetics analysis
