摘要
目的了解肺炎链球菌的耐药特点。方法回顾性分析2013年-2014年临床分离肺炎链球菌的分布及其耐药性。结果 218株肺炎链球菌主要分离自呼吸道标本,其次为血液和脑脊液标本。青霉素耐药肺炎链球菌(PRSP)在儿童及成人组中的检出率分别为59.4%(57/96)和32.0%(39/122),儿童组高于成人组,差异有统计学意义(P<0.01)。非侵袭性和侵袭性标本来源PRSP分别占50.8%(90/177)和14.6%(6/41),差异具有统计学意义(P<0.01)。肺炎链球菌对大环内酯类抗生素、克林霉素、四环素及复方新诺明的耐药率较高,未发现头孢吡肟、左氧氟沙星和万古霉素耐药菌株。结论大环内酯类抗生素已不适宜作为肺炎链球菌呼吸道感染的一线经验用药。不同人群、不同标本来源分离的肺炎链球菌对青霉素的耐药性存在差异。
Objective To investigate the characteristics of drug resistance of Streptococcus pneumonia. Methods The distribution and drug resistance of Streptococcus pneumonia isolated from 2013 to 2014 were retrospectively analyzed. Results 218 strains of Streptococcus pneumonia were mainly isolated from respiratory specimens,followed by blood samples and cerebrospinal fluid specimens. The difference was statistically significant on the detection rate of Penicillin resistant Streptococcus pneumoniae（ PRSP） between children（ 59. 4%,57 /96） and adults（ 32. 0%,39 /122）（ P〈0. 01）. There was statistical significance on the difference between noninvasive source specimens（ 50. 8%,90 /177） and invasive source（ 14. 6%,6 /41）（ P〈0. 01）. The resistance rate of Streptococcus pneumonia to macrolides antibiotic,clindamycin,tetracycline and bactrim were extremely high.Streptococcus pneumonia resistant to cefepime,levofloxacin and vancomycin were not found. Conclusion Macrolides antibiotic is not suitable as main medication for Streptococcus pneumonia respiratory infection. The resistance rates of Streptococcus pneumoniae to Penicillin in different sources are different.
出处
《中国卫生检验杂志》
CAS
2016年第10期1509-1511,共3页
Chinese Journal of Health Laboratory Technology
关键词
肺炎链球菌
抗生素耐药性
非侵袭性
侵袭性
人群
比较
Streptococcus pneumonia
Antibiotic resistance
Noninvasive
Invasive
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