摘要
HBV前S/S区基因突变可以是自发的,也可以是外界压力选择的结果。突变株可通过输血、器官移植、分娩等造成HBV感染,也可以引起急性、慢性和隐匿性HBV感染。HBV前S/S基因突变可导致病毒生物学特点和免疫应答发生改变,引起免疫逃逸、疫苗预防失败、HBs Ag阴性感染和疾病重症化等,与肝硬化和肝癌的进展也有密切关系,从而影响HBV慢性感染的临床转归。
HBV pre S/S gene mutations may occur spontaneously or may be the consequence of selection by outside pressures. The viral mutants may induce HBV infection through blood transfusion, organ transplantation and mother-to-children transmission, or cause acute, chronic and occult HBV infection. The HBV pre S/S gene mutations may lead to the change of biological characteristics of the virus and the immune responses, causing immune escape, immunoprophylaxis failure, HBs Ag-negative HBV infection and the aggravation of the disease. It suggests that the mutations are associated with the development of liver fibrosis and hepatocellular carcinoma, therefore affecting clinical outcome of chronic HBV infection.
出处
《传染病信息》
2016年第2期112-116,共5页
Infectious Disease Information
基金
国家自然科学基金项目(81373136
81271847)
关键词
乙型肝炎病毒
基因型
突变
疾病恶化
hepatitis B virus
gene type
mutation
disease progression
