摘要
目的:明确从肿瘤内环境Ca^(2+)/Mg^(2+)同结肠癌患者预后及中医体质之间关系,以期探索中医药从调节体质、体内环境角度干预结肠癌预后可行性。方法:以2012年1月—2014年12月期间、在上海市中医医院就诊的结肠癌(Ⅲ、Ⅳ期)患者为研究对象,通过调查问卷及测定饮食、血清中Ca^(2+)/Mg^(2+),对其进行方差及Cox多因素模型分析。结果:(1)气虚型、阳虚型、血瘀型体质与血Ca^(2+)/Mg^(2+)存在统计学关联性,所有体质与食物Ca^(2+)/Mg^(2+)均无统计学关联性;(2)血清Ca^(2+)/Mg^(2+)每上升1个单位,肠癌患者的死亡风险上升2.35倍,食物Ca^(2+)/Mg^(2+)同死亡风险无统计学关联;(3)体质中仅血瘀质体质同结肠癌患者生存期有统计学意义。结论:肿瘤内环境Ca^(2+)/Mg^(2+)同结肠癌患者预后及中医体质之间相关,应通过中医药调整患者体质,改善肿瘤内环境,延长患者生存期。
Objective： To confirm the relationship between the prognosis and TCM constitution from tumor environment about the ratio of Ca^（2＋）/Mg^（2＋）in the colon cancer patients and explore the feasibility of prognosis of colon cancer between the Chinese medicine intervention of the regulation constitution and in vivo environment. Methods： In January 2012- December 2014,the patients in the Shanghai Hospital of traditional Chinese medicine were treated as the research object,through the questionnaire and the determination of the concentration of Ca^（2＋）/Mg^（2＋）in dietary and serum,and then we analyzed its variance and Cox multiple factor model. Results：（ 1） Constitution of qi deficiency,Yang deficiency,blood stasis syndrome and blood Ca^（2＋）/Mg^（2＋）were statistically correlated. All physical constitutions had no statistical correlation with food Ca^（2＋）/Mg^（2＋）ratio.（ 2） The concentration of Ca^（2＋）/Mg^（2＋）in serum increased per unit,the death risk of patients with colorectal cancer increased 2. 35 times. The concentration of Ca^（2＋）/Mg^（2＋）in food had no statistically association with mortality risk.（ 3） Statistical significance only existed in blood stasis constitution and colon cancer patients＇ survival period in all constitutions. Conclusion： Ca^（2＋）/Mg^（2＋）in tumor environment is associated with the prognosis of patients with colon cancer and TCM constitution. They should adjust patients by traditional Chinese medicine constitutions and improve the environment for tumor so to prolong patients＇ survival.
出处
《辽宁中医杂志》
CAS
北大核心
2016年第5期911-914,共4页
Liaoning Journal of Traditional Chinese Medicine
基金
上海市卫生局青年基金(20124Y019)
关键词
结肠癌
钙镁比例
体质
预后
colon cancer
Ca2＋/Mg2＋
constitution
prognosis
