摘要
从雷公藤（ＴｒｉｐｔｅｒｙｇｉｕｍｗｉｌｆｏｒｄｉｉＨｏｏｋ．ｆ．）根皮中分离到二个倍半萜生物碱，即碱Ⅰ和碱Ⅱ，根据理化性质和光谱（ＵＶ，ＩＲ，ＭＳ，ＨＲＭＳ，ｌＨＮＭＲ，１３ＣＮＭＲ（ＣＯＭ和ＯＦＲ），１Ｈ－１ＨＣＯＳＹ，１Ｈ－１３ＣＣＯＳＹ，ＮＯＥＳＹ和ＣＯＬＯＣ］解析，鉴定生物碱Ⅰ为ｅｕｏｎｙｍｉｎｅ，生物碱Ⅱ为一种新的生物碱，命名为雷公藤明碱（ｗｉｌｆｏｒｄｓｉｎｅ）。初步药理实验证明雷公藤明碱有免疫抑制活性。
Two sesquiterpene alkaloids , euonymine and wifordsine
were isolated from Triterygium wilfordii Hook.f.wilfordsine is a new
alkaloid. The structure of wilfordsine andeuonymine were elucidated
on the basis of UV,I,MS,HRMS,1HNMR,13CNMK,COSY,NOESY and COLOC
methods. Wilfordsine was shown to be immunosuppressive.
出处
《药学学报》
CAS
CSCD
北大核心
1995年第7期513-516,共4页
Acta Pharmaceutica Sinica
关键词
雷公藤
倍半萜生物碱
雷公藤明碱
免疫抑制
Tripterygium wilfordii
Sesquiterpene alkaloid
Euonymine
Wilfordsine
Immunosup-pressive
