摘要
目的初步探讨脱氢表雄酮（DHEA）对卵巢低反应患者的卵巢储备功能和体外受精-胚胎移植（IVF-ET）周期的影响。方法筛选2012-07～2013-07间IVF-ET治疗失败的卵巢低反应患者76例,给予DHEA口服（75 mg/d）,治疗3个月后再次接受IVF-ET治疗。分三个不同年龄段（〈35岁,35-40岁,〉40岁）比较服用DHEA前后卵巢储备功能的变化以及再次IVF-ET的周期参数和妊娠结局。结果与服药前相比,三个不同年龄段患者的基础窦卵泡数有增加趋势,雄激素水平显著升高（P〈0.01）,卵泡刺激素（FSH）、雌二醇（E2）的水平明显降低（P〈0.05）。IVF-ET治疗过程中,促性腺激素（Gn）显著降低（P〈0.05）,获得了19.73%（15/76）临床妊娠率。结论 DHEA能提高卵巢低反应患者的雄激素水平,有效改善卵巢储备功能和再次IVF-ET的妊娠结局。
Objective To evaluate the effect of dehydroepiandrosterone（ DHEA） supplementation on ovarian reserve and in vitro fertilization and embryo transfer（ IVF-ET） outcomes in women with poor ovarian response. Methods Seventy-six women with poor ovarian response（ at least one IVF cycle failure） from July 2012 to July 2013 received 75 mg DHEA daily for three months. Patients were divided into three groups according to the age. Antral follicle count（ AFC）,follicle stimulating hormone（ FSH）,estradiol（ E2）,testosterone（ T）,progesterone（ P） and IVF outcome parameters were compared before and after the DHEA treatment. Results In all three groups,AFC mildly increased,the serum levels of T increased significantly（ P〈0. 01）,while FSH and E2 levels decreased significantly after DHEA supplementation（ P〈0. 05）. IVF cycle outcomes demonstrated significant decrease of Gn amount after the DHEA treatment（ P〈0. 05）. Finally,fifteen women conceived with a clinical pregnancy rate of 19. 73%. Conclusion DHEA supplementation could significantly increase the androgen level in women with poor ovarian response,which could improve ovarian reserve and the pregnancy rate.
出处
《山西医科大学学报》
CAS
2016年第5期470-474,共5页
Journal of Shanxi Medical University
基金
陕西省社会发展科技攻关基金资助项目(2015SF122)
关键词
脱氢表雄酮
卵巢低反应
卵巢储备功能
体外受精-胚胎移植
妊娠率
dehydroepiandrosterone
poor ovarian response
ovarian reserve function
in vitro fertilization and embryo transfer
pregnancy rate
