摘要
目的:研究单侧输卵管切除术对体外受精-胚胎移植(IVF-ET)周期卵巢反应性和妊娠结局的影响。方法:以行IVF-ET单侧输卵管切除的106例不孕患者为研究组,同期双侧输卵管梗阻的患者360例为对照组,比较研究组输卵管切除后术侧和健侧超促排卵启动日卵巢的大小和窦卵泡数、hCG注射日卵巢的大小、≥12mm卵泡数和获卵数,同时比较研究组和对照组≥12mm卵泡数、获卵数、受精数、优质胚胎数以及Gn用量、用药天数、妊娠率。结果:研究组中术侧和健侧启动日卵巢的大小无显著性差异,然而超促排卵启动日窦卵泡数、hCG注射日双侧卵巢大小、≥12mm卵泡数和获卵数均有统计学差异。研究组无论是hCG注射日≥12mm卵泡数、获卵数、Gn用量、用药天数,还是受精数、优胚数和妊娠率与对照组比较,均无显著性差异。结论:单侧输卵管切除术降低同侧卵巢的反应性,但总体上不影响卵巢对Gn的反应和IVF-ET妊娠结局。
Objective： To evaluate the effect of unilateral salpingectomy on ovarian response to superovulation and the outcome during in vitro fertilization and embryo transfer （IVF-ET） treatment cycles. Methods： A total of 106 patients with unilateral salpingectomy （study group） and 360 infertile patients with obstruction of bilateral fallopian tube （control group） underwent IVF-ET treatment. The ovarian size and the number of antral follicles on the priming day, the ovarian size and the number of ≥ 12 mm follicles on the day of hCG injection and oocytes retrieved were compared between the operated side and intact side in study group. The total number of ≥12 mm follicles on the day of hCG injection, the number of oocytes retrieved, the number of fertilized oocytes and good quality embryos, ampules and days of gonadotropin （Gn） and prengnacy rate were also analyzed between study group and control group. Results： Compared with intact side in study group, the ovarian size and the number of ≥ 12 mm follicles on the day of hCG injection, the number of antral follicles on the priming day and oocytes retrieved were significantly different on operated side but the ovarian size was similar on the priming day. No difference was found between study and control groups in the following outcome measures investigated： the total number of ≥ 12 mm follicles on the day of hCG injection, oocytes retrieved, fertilized oocytes and good quality embryos, and ampules and days of gonadotropin （Gn） and prengnacy rate. Conslusion： These findings suggest that unilateral salpingectomy may compromise ipsilateral ovarian response to stimulation without affecting the whole ovarian response to stimulation and pregnancy outcome in IVF-ET treatment cycles.
出处
《生殖与避孕》
CAS
CSCD
北大核心
2010年第1期59-62,共4页
Reproduction and Contraception
