摘要
目的分析脱氢表雄酮(DHEA)预处理联合生长激素(GH)对卵巢储备功能低下(DOR)体外受精-胚胎移植(IVF-ET)患者妊娠结局及卵巢储备功能的影响。方法选取2018年1月—2019年1月收治的DOR IVF-ET患者112例,根据治疗方法的不同分为观察组58例和对照组54例,观察组给予DHEA预处理,并在IVF-ET治疗过程中加用GH;对照组仅常规给予IVF-ET治疗。比较2组促排卵参数、胚胎发育指标、卵巢储备功能指标、妊娠结局,以及不良反应情况。结果观察组尿促卵泡素用药量少于对照组,尿促卵泡素用药时间短于对照组,人绒毛膜促性腺激素注射日内膜厚度大于对照组,获卵数、可利用胚胎数及优质胚胎数均多于对照组(P<0.05,P<0.01)。治疗后,2组卵泡刺激素(FSH)、雌二醇(E 2)较治疗前降低,抗苗勒管激素(AMH)、孕酮(P)较治疗前升高,且观察组FSH、E 2降低,以及AMH、P升高程度均大于对照组(P<0.05,P<0.01)。观察组种植率及临床妊娠率均高于对照组(P<0.05);2组流产率比较差异无统计学意义(P>0.05)。治疗期间2组均未发生明显不良反应。结论DHEA预处理联合GH可增强DOR IVF-ET患者卵巢反应性,减少尿促卵泡素用药量及缩短用药时间,提高卵巢储备功能,改善患者妊娠结局。
Objective To analyze the effect of Dehydroepiandrosterone(DHEA)pretreatment combined with Growth Hormone(GH)on the pregnancy outcome and ovarian reserve function of patients with ovarian reserve dysfunction(DOR)undergoing in vitro fertilization embryo transfer(IVF-ET).Methods A total of 112 patients with DOR undergoing IVF-ET treated from January 2018 to January 2019 were divided into observation group(n=58)and control group(n=54)according to different treatment methods.The observation group was given DHEA pretreatment and GH was added during IVF-ET treatment,while the control group was only given conventional IVF-ET treatment.The parameters of ovulation induction,embryo development,ovarian reserve function,pregnancy outcome and adverse reactions were compared between the 2 groups.Results The dosage of urofollitropin in the observation group was less than that in the control group,and the duration of urofollitropin administration was shorter than that in the control group,the intimal thickness on the day of human chorionic gonadotropin injection was greater than that in the control group,and the number of oocytes retrieved,available embryos and high-quality embryos were more than those in the control group(P<0.05,P<0.01).After treatment,follicle stimulating hormone(FSH)and estradiol(E 2)in the two groups were lower than those before treatment,anti-Müllerian hormone(AMH)and progesterone(P)were higher than those before treatment,FSH and E 2 were decreased,AMH and P were increased more in the observation group than in the control group(P<0.05,P<0.01).The implantation rate and clinical pregnancy rate in the observation group were higher than those in the control group(P<0.05),and there was no significant difference in the abortion rate between the two groups(P>0.05).No significant adverse reactions occurred in both groups during the treatment period.Conclusion DHEA pretreatment combined with GH can enhance ovarian responsiveness,reduce the dosage of urofollitropin,shorten the time of administration,improve ovarian r
作者
孟靠
马娟
王振
MENG Kao;MA Juan;WANG Zhen(Department of Medical Reproduction,General Hospital of Wanbei Coal-electricity Group,Suzhou,Anhui 234000,China)
出处
《解放军医药杂志》
CAS
2020年第9期93-97,共5页
Medical & Pharmaceutical Journal of Chinese People’s Liberation Army
基金
蚌埠医学院自然科学类项目计划书(BYKY2019244ZD)。
关键词
卵巢储备功能低下
体外受精-胚胎移植
脱氢表雄酮
生长激素
妊娠结局
尿促卵泡素
胚胎发育
Ovarian reserve dysfunction
In vitro fertilization-embryo transfer
Dehydroepiandrosterone
Growth hormone
Pregnancy outcome
Urofollitropin
Embryonic development
