摘要
表观遗传学是中医疾病证候多样化之根源,也是肿瘤中医辨证论治之微观立足点,又是基因组稳定性的保证,而肿瘤微环境是中医肿瘤辨证论治之物质基础,两者均与肿瘤细胞的基因组不稳定性密切相关。肿瘤微环境及其表观遗传机制在肿瘤发生机制中发挥了决定性作用。表观遗传机制是联系中医证本质和肿瘤微环境之间的纽带;将表观遗传学引入中医证本质的研究,有望成为中医现代化一个较有前途的切入点。
Epigenetics is the root of the diversification of TCM disease syndromes, and the micro-foothold of TCM differentiation and treatment of tumors, and also the guarantee of genomte stability. The micro-environment of tumors is the material basis of TCM differentiation and treatment of tumors. Both of them are closely related to the genomic instability of cancer cells. Tumor microenvironment and its epigenetic mechanism play a decisive role in tumorigenesis. Epigenetic mechanism is the link between the essence of TCM syndrome and the micro-environment of tumors. It is hopeful that introducing epigenetics into the study of TCM syndrome essence will become a promising entry point for the modernization of TCM.
作者
马萌
MA Meng(Science and Technology Laboratory Center,Shanghai University of Traditional Chinese Medicine,Shanghai 201203,China)
出处
《中华中医药杂志》
CAS
CSCD
北大核心
2019年第3期905-911,共7页
China Journal of Traditional Chinese Medicine and Pharmacy
关键词
表观遗传学
中医证本质
肿瘤微环境
基因组不稳定
免疫逃逸
肿瘤阴阳
Epigenetics
Essence of TCM syndrome
Tumor microenvironment
Genomic instability
Immune escape
Yin and yang attribute of tumor
