摘要
进行性核上性麻痹是一种少见的进行性加重的神经系统变性疾病,多隐匿起病,早期易误诊。其主要临床表现为进行性核上性眼肌麻痹、假性球麻痹、轴性肌张力障碍、认知功能障碍、构音障碍等。影像学尤其是MRI在进行性核上性麻痹诊断中起重要作用,组织病理检查是诊断金标准。对症支持治疗是进行性核上性麻痹的主要治疗方法,但疗效不持久。本文就进行性核上性麻痹发病机制、临床特点、诊断和治疗等研究进展作一综述。
Progressive supranuclear palsy （PSP） is a rare progressive neurodegenerative disease, and is easily misdiagnosed in the early period due to insidious onset, which is clinically demonstrated by nuclear ophthalmoplegia palsy, pseudobulbar palsy, axial dystonia, cognitive dysfunction, structure of the sound barrier, etc. Neuroimaging, especially MRI, plays an important role in the diagnosis of PSP. The histopathological result is regarded as the gold standard. PSP is mainly treated by symptomatic and supportive therapy, but the effect is not lasting. This paper reviews the research progress of the pathogenesis, clinical features, diagnosis and treatment of PSP.
出处
《中华实用诊断与治疗杂志》
2016年第5期429-431,共3页
Journal of Chinese Practical Diagnosis and Therapy
基金
国家卫生计生委重点临床专科建设项目(2012)
