摘要
目的:概述近10年以β淀粉样蛋白为靶标中医药防治阿尔茨海默病的实验研究。方法:应用计算机在中国知网(CNKI)、万方及维普数据库检索2004至2014年所有关于中医药影响β淀粉样蛋白的研究,检索词为"β淀粉样蛋白",排除与研究内容不相关的文献,对最终得到的文献进行系统分析。结果:单味药、复方、针灸等中医药疗法均能影响β淀粉样蛋白的水平及功能。结论:中医药调节β淀粉样蛋白的可能机制是减少Aβ生成、降低Aβ表达、拮抗Aβ神经毒性、抑制Aβ相关的β和γ分泌酶的活性、减少脑内Aβ含量和沉积等,从而发挥防治阿尔茨海默病的作用。
Objective： To review the experimental study on Chinese medicine used regulation of amyloidal beta protein of the past ten years. Methods： Retrieval the Knowledge about traditional Chinese medicine effects on βamyloid through CNKI, Wan Fang and VIP database from 2004 to 2014, searching for the word ＂amyloid beta protein＂, eliminating researches literature not related to the content, make a systematic analysis of the literature research finally. Results： The single herb, Chinese compound medicine, acupuncture and moxibustion can affect the levels and function of amyloid beta. Conclusion： The possible mechanism of traditional Chinese medicine regulate amyloid beta protein level is mainly by changing the beta amyloid precursor protein （APP） in order to reduce the metabolic pathways of A beta peptide formation, reducing the expression of brain A beta, antagonistic of beta polypeptide neurotoxicity, inhibition of A β related beta and gamma-secretes activity, reducing the content and deposition of A βin brain to prevent Alzheimer＇s disease.
出处
《中国中医基础医学杂志》
CAS
CSCD
北大核心
2015年第4期403-405,419,共4页
JOURNAL OF BASIC CHINESE MEDICINE
基金
辽宁省高等学校优秀人才支持计划(LR2011027)
辽宁省科学技术计划社会发展攻关计划(2010225027)
沈阳市科技厅项目(F11-262-9-48)
关键词
中医
中药
Β淀粉样蛋白
实验研究
Traditional Chinese medicine
Chinese herbs
Amyloid beta protein
Experimental study
