摘要
目的:探讨血清C-反应蛋白(CRP)和降钙素原(PCT)在儿童社区获得性肺炎(CAP)病情严重程度评估中的作用。方法:选取62例符合CAP诊断标准的儿童患者(CAP组)及57例体检健康的正常儿童(对照组)作为研究对象,根据儿童病情严重程度将CAP组分为重症组(28例)和轻症组(34例),检测所有儿童血清CRP及PCT水平,并进行比较分析。结果:CAP组患儿的血清CRP及PCT水平分别为(12.49±2.76)mg/L和(1.622±0.105)ng/m L,均显著高于健康儿童的CPR和PCT水平[(5.37±1.81)mg/L和(0.051±0.003)ng/m L],差异有统计学意义(t值分别为8.736、9.251,P<0.01);重症组患儿的PCT水平为(2.445±0.134)ng/m L,显著高于轻症组的(1.019±0.157)ng/m L(t=8.976,P<0.01),但重症组患儿的CPR水平[(12.75±2.11)mg/L]与轻症组[(12.17±2.03)mg/L]比较差异无统计学意义(t=0.896,P>0.05)。结论:CAP患儿的血清CRP及PCT水平均明显升高,但应用PCT作为CAP病情严重程度评估的指标较CRP更为有效。
Objective： To investigate the role of serum C-reactive protein（ CRP） and procalcitonin（ PCT） in the severity evaluation of children with community-acquired pneumonia（ CAP）.Methods： A total of 62 children accordant with the CAP diagnosis standard（ CAP group） and a total of 57 healthy children（ control group） were selected as research objects. According to children＇s condition,the children of CAP group were further divided into the severe group（ 28 cases） and the mild group（ 34 cases）. The levels of serum C-reactive protein（ CRP） and procalcitonin（ PCT） were detected and analyzed.Results： The levels of serum CRP and PCT in the CAP group were significantly higher than those in control group（ t = 8.736,9.251,P0.01）,the level of PCT in severe group was obviously higher than that in mild group（ t = 8.976,P 0.01）,but there was no significant statistical difference between severe group and mild group in the level of CRP（ t = 0.896,P 0.05）. Conclusion： The levels of serum CRP and PCT both rise obviously in children with CAP,but PCT is a better indicator than CRP in the severity evaluation in children with CAP.
出处
《儿科药学杂志》
CAS
2016年第5期4-6,共3页
Journal of Pediatric Pharmacy
关键词
C-反应蛋白
降钙素原
儿童
社区获得性肺炎
病情评估
C-reactive protein
procalcitonin
children
community-acquired pneumonia
severity evaluation
