摘要
肿瘤的免疫逃逸是癌症的一大特征，目前所知的肿瘤逃逸机制主要包括肿瘤的直接免疫逃逸和肿瘤微环境介导的免疫逃逸。鼻咽癌的发生发展与其肿瘤细胞的免疫逃逸密切相关，其中与鼻咽癌相关的肿瘤的直接免疫逃逸主要包括肿瘤细胞表面主要组织相容性复合体-I类分子表达下降或缺失、肿瘤细胞缺乏共刺激分子以及Fas／FasL系统介导的免疫逃逸；与鼻咽癌相关的肿瘤微环境介导的免疫逃逸则包括肿瘤相关免疫抑制分子和肿瘤相关免疫抑制性细胞。研究鼻咽癌免疫逃逸的作用机制能够为其治疗及预防提供新的研究方向。
Tumor immune evasion is a hallmark of cancer. There are many mechanisms of tumor escape, which mainly include the direct immune escape of tumor and tumor microenvironment mediated immune escape. Recent studies have shown that the development of nasopharyngeal carcinoma and its tumor cells are closely related to the immune escape. The direct immune escape of tumor which is associated with nasopharyn- geal carcinoma including the expression decreased or absent of the major histocompatibility complex- I on the surface of tumor cell, the lack of costimulatory molecules of tumor and the Fas/FasL system mediated immune escape. And the tumor microenvironment mediated immune escape which is associated with nasopharyngeal car- cinoma including the immunosuppressive molecule and the immunosuppressive cells of tumor. Researches on the mechanisms of tumor immune evasion can provide new target for treatment and prevention of nasopharyngeal carcinoma.
出处
《国际肿瘤学杂志》
CAS
2016年第5期372-375,共4页
Journal of International Oncology
基金
国家自然科学基金（81260312）
云南省卫生科技计划（2012WS0035）
昆明市西山区科技计划（西科字50号）
关键词
鼻咽肿瘤
肿瘤逃逸
Nasopharyngeal neoplasms
Tumor escape
