摘要
目的探讨常州市武进地区汉族人群中不同时间血清胎球蛋白A(Fetuin-A)水平与不稳定型心绞痛(UAP)发病风险的相关性。方法收集2011年—2012年常州市武进人民医院住院病人114例,其中UAP病人69例,作为病例组,冠状动脉完全无病变者45例作为对照组。收集一般资料(性别、吸烟史、高血压病、糖尿病等);并收集病人血清常规生化检测总胆固醇(TC)、三酰甘油(TG)、高密度脂蛋白(HDL-C)、低密度脂蛋白(LDL-C);采用酶联免疫吸附法,测定两组病人血清Fetuin-A水平;经Logistic回归分析校正UAP易患因素后两组间差异。结果临床资料比较,病例组男性比例较高,高血压病及糖尿病病人较多(P<0.005);两组间年龄、吸烟史、TC、TG、HDL-C及LDL-C差异无统计学意义(P>0.05)。病例组血清Fetuin-A水平为(282.87±101.11)g/L,对照组为(278.02±137.10)g/L,两组间差异无统计学意义(t=0.187,P=0.839)。进一步行Logistic回归分析校正性别、吸烟、血压、血糖等冠心病易患因素后仍未发现有明显差异(P=0.086)。经多元线性回归分析后发现,UAP病人Fetuin-A水平与性别、年龄、吸烟史、高血压病、糖尿病和血清TC、TG、HDL-C及LDL-C含量无明显相关性(P>0.05)。结论在中国常州市武进地区汉族人群中血清Fetuin-A水平可能与UAP发病风险无关。
Objective To investigate the association between serum fetuin-A level and the risk of unstable angina pectoris（ UAP） in Han population of Chinese Changzhou Wujin region. Methods One hundred and fourteen hospitalized patients were collected during 2011 to 2012 in our hosipital,of which 69 patients with UAP in case group,45 patients without coronary artery pathological changes in control group. General information were collected,including gender,smoking history,history of hypertension,diabetes,et al. Then collected biochemical results,including TC,TG,HDL-C and LDL-C. Serum fetuin-A level was measured by enzyme-linked immunosorbent assay. The differences between two groups after adjustment for UAP susceptibility were analysed by Logistic regression. Results The general clinical data were compared between the two groups,the male,hypertension and diabetes ratio was higher in case group（P〈0. 05）. The fetuin-A levels was（ 282. 87 ±101. 11） g / L in UAP patients and was（ 278. 02 ± 137. 10） g / L in control group. There was no significant statistical difference between two groups（t = 0. 187,P = 0. 839）. There was no significant statistical difference between the two groups after adjusted UAP risk factors analyzed by multivariate Logistic regression analysis（P = 0. 086）. The serum fetuin-A level was unrelated with gender,age,history of hypertension,diabetes or smoking,and dyslipidemia（P〈0. 05）. Conclusion The serum fetuin-A level may be no association with UAP in Han population of Chinese Changzhou Wujin region.
出处
《中西医结合心脑血管病杂志》
2016年第7期740-742,共3页
Chinese Journal of Integrative Medicine on Cardio-Cerebrovascular Disease
