摘要
目的回顾性分析成人脑胶质瘤的病理特点及临床预后,研究影响成人脑胶质瘤预后的相关因素。方法选取2011年1月—2014年12月北京天坛医院神经外科诊治的资料符合本研究要求的脑胶质瘤患者123例,采用Kaplan-Meier生存曲线法、Log-Rank单因素分析及Cox多因素分析对患者的年龄、性别、肿瘤病理分级、手术切除范围、肿瘤大小、术前癫及水肿、术前KPS评分,术后放化疗及肿瘤标志物Ki-67等十项指标进行统计学分析。结果 Log-Rank单因素分析与Cox多因素分析结果提示患者年龄(P=0.0020)、术前KPS评分(P=0.0008)、肿瘤病理分级(P<0.0001)、是否进行术后放疗(P<0.0001)、及Ki-67水平(P=0.0101)是影响胶质瘤患者预后的独立因素。结论患者术前KPS评分越低、年龄越大、病理级别越高、Ki-67表达量越高、未采取术后放疗,则预后越差。
Objective To analyze the clinical data of 123 glioma patients and study the pathological characteristics and prognosis retrospectively,and determine the multi-factors that affects the prognosis of patients with glioma.Methods Toally 123 patients from Jan 2011 to Dec 2014 in Beijing Tiantan hospital were enrolled in this research.Potential risk factors including age,sex,pathological grade,surgical resection scale,size of the tumor,epilepsy and edema before surgery,pre-operative KPS score,post-surgery radiotherapy and chemotherapy,and Ki-67 as a tumor marker were analyzed by Kaplan-Meier survivorship curve,univariate Log-rank analysis,followed by multivariate analysis Cox regression model.ResultsThrough univariate Log-rank analysis and Cox multivariate analysis,age（P=0.0020）,pre-operative KPS score（P=0.0008）,tumor pathological grade（P〈0.0001）,post-operative radiotherapy（P〈0.0001）,and Ki-67 level（P=0.0101）were the independent prognostic factors of patients with glioma.Conclusion Age〈60 years old,KPS score≥70,pathological grade I and II,low Ki-67 level and radiotherapy indicate better prognosis for glioma pathients.
出处
《中国煤炭工业医学杂志》
2016年第4期543-548,共6页
Chinese Journal of Coal Industry Medicine
关键词
脑胶质瘤
预后
手术
放疗
化疗
Glioma
Prognosis
Surgery
Radiotherapy
Chemotherapy
