摘要
目的研究腹膜后恶性副神经节瘤免疫组化与患者预后的关系。方法回顾性分析我院1985年1月1日-2015年1月1日诊治的17例病理诊断为恶性副神经节瘤患者的免疫组化情况及其与预后的关系。结果 17例中Ki-67阳性5例,死亡8例中Ki-67阳性4例。CgA阳性9例,死亡8例中CgA阳性5例。3种以上免疫组化肿瘤细胞和支持细胞标记物阳性10例,死亡8例中3种以上免疫组化肿瘤细胞和支持细胞标记物阳性6例。本组病例远处转移8例,死亡8例中远处转移6例。结论原发性腹膜后恶性副神经节瘤其肿瘤免疫组化与预后相关。
Objective To study the relationship between immunohistochemical markers and prognosis of patients with primary retroperitoneal extra-adrenal malignant paraganglioma（MPGL）. Methods A retrospective analysis of immunohistochemical markers and prognosis of 17 patients with pathological diagnosis as MPGL from January 1985 to January 2015 was carried out, and the relationship between them was analyzed. Results Of the 17 patients, 8 cases died, 5 cses were Ki-67 positive, 9 cases were CgA positive, 10 patients with more than 3 kinds of chief cells and sustentcular cells detected to be positive by immunohistochemistry, and 8 cases with distant metastasis. Of the 8 dead patients, 4 were Ki-67 positive, 5 cases were CgA positive, 6 patients with more than 3 kinds of chief cells and sustentcular cells detected to be positive by immunohistochemistry, and 6 cases with distant metastasis. Conclusion There is a certain correlation between immunohistochemical markers and prognosis of MPGL.
出处
《解放军医学院学报》
CAS
2016年第4期320-323,共4页
Academic Journal of Chinese PLA Medical School
基金
北京市首都医学发展科研基金(2011-5001-03)~~
关键词
恶性副神经节瘤
预后
免疫组化
malignant paraganglioma
prognosis
immunohistochemistry
