摘要
目的:探讨原发性腹膜后副神经节瘤的手术治疗效果,复发及死亡的影响因素。方法:回顾性分析1985年1月至2015年1月30年间于我院治疗的91例原发性腹膜后副神经节瘤的手术患者的临床资料,统计学方法分析腹原发性腹膜后副神经节瘤手术的治疗效果,预后及复发和死亡的相关因素。结果:77例原发性腹膜后良性副神经节瘤患者,l、3、5年总生存率均为98.5%,复发率分别为2%,4.5%,16%。手术根治度与复发相关(X^2=10.368,P=0.01),手术未完整切除复发率高。性别、年龄、肿瘤部位、肿瘤直径与复发无关(P>0.05)。14例原发性腹膜后恶性副神经节瘤患者,1、3、5年总生存率分别为78.5%、50%,41.5%。14例恶性副神经节瘤复发率分别为71%,85%,100%。肿瘤级别与腹膜后恶性副神经节瘤预后(X^2=5.536,P=0.019)和复发相关(X^2=5.734,P=0.017),肿瘤级别低,死亡率高,复发率高;远处转移与复发相关(X^2=4.067,P=0.044),远处转移患者复发率高;性别、年龄、肿瘤部位、肿瘤直径、手术根治度与预后及复发无关(P>0.05)。结论:良性腹膜后副神经节瘤患者预后较好,手术根治度与复发相关,根治性手术是其主要治疗方式;恶性副神经节瘤预后差,肿瘤分级与其复发及死亡相关,肿瘤分级低复发及死亡率高,远处转移与复发相关,远处转移患者复发率高。
To evaluate the surgical efficacy of primary retroperitoneal extra-adrenal paraganglioma and analyze its risk factors for survival and recurrence. Methods： From January 1985 to January 2015, 91 patients diagnosed with primary retroperitoneal extra-adrenal paraganglioma were treated in our hospital.And their clinical data were retrospectively analyzed to investigate the related risk factors of prognosis of this disease. Results： The overall1,3,5-year survival rate of benign primary retroperitoneal extra-adrenal paraganglioma was 98.5 % and the recurrence rate was 2 %, 4.5 %, 16 %. Univariate analysis revealed the modus operation of tumor resection were associated with recurrence rate（X^2=10.368, P=0.01）, the recurrence rate was high for the patients with incomplete resection. The diameter and location of tumor, age, gender had no obvious association with recurrence rate（P〈0.05）. The overall1,3,5-year survival rate and recurrence rate of primary retroperitoneal extra-adrenal maligant paraganglioma was 78.5 %, 50 %, 41.5 and71 %, 85 %, 100 %, respectively. Univariate analysis revealed, tumor grade was associated with prognosis（X^2=5.536, P=0.019） and recurrence（X^2=5.734, P=0.017） of the primary retroperitoneal extra-adrenal maligant paraganglioma, the tumor grade was lower, the mortality and recurrence rate was higher; the distant metastasis was related to recurrence（X^2=4. 067, P=0.044）, the patients with distant metastasis had higher recurrence. Conclusions： The prognosis is good in patients with benign retroperitoneal paraganglioma, and the complete surgical treatment is the main treatment method, and the modus operation of tumor resection is associated with recurrence rate;while the prognosis is poor in primary retroperitoneal extra-adrenal maligant paraganglioma, and tumor grade is associated with prognosis and recurrence, and the distant metastasis is related to recurrence.
出处
《现代生物医学进展》
CAS
2016年第8期1506-1508,1527,共4页
Progress in Modern Biomedicine
基金
北京市首都医学发展科研基金项目(2011-5001-03)
关键词
腹膜后肿瘤
副神经节瘤
复发
预后
Retroperitoneal neoplasms
Paraganglioma
Recurrence
Prognosis
