摘要
目的研究大黄对严重烧伤后家兔胃肠吸收功能的改善作用。方法将72只家兔随机分为4组,分别为假伤组、对照组、口服补液组、口服补液+大黄组。假伤组给予备皮但不烧伤,对照组给予制造烧伤面积40%Ⅲ度背部烧伤模型,口服补液组的制作同对照组给予口服补液抗休克,口服补液+大黄组的制作同对照组给予口服补液+大黄治疗。于干预24h后测定各组的胃黏膜血流、血清胃泌素、尿液木糖排泄率、溃疡指数。结果口服补液+大黄组的胃黏膜血流、溃疡指数、血清胃泌素及尿D-木糖排泄率测定与假伤组、对照组、口服补液组比较差异有统计学意义(P<0.05)。结论大黄可以改善胃黏膜血流,降低溃疡指数,升高胃泌素,提高D-木糖排泄率,提高胃肠吸收功能。
Objective To observe the effects of rhubarb in protection of gastrointestinal absorption function on serious burn of rabbit. Methods 72 rabbits were randomly divided into four groups,namely sham group,control group,oral rehydration group,oral rehydration ＋ rhubarb group. Sham group received skin preparation but not burn. Control group were given manufacturing 40% TBSAⅢ° back burn model. Oral rehydration group were given oral rehydration anti-shock after making the same burn model. Oral rehydration ＋ rhubarb group were given oral rehydration and rhubarb anti-shock. Gastric mucosal blood flow,Gastrin（ GAS）,D-xylose urine excretion rate,ulcer index（ UI） were calculated for each group at 24 hours after intervention. Results Oral rehydration ＋ rhubarb group was improved obviously than control group and oral rehydration group at gastric mucosal blood flow,GAS,D-xylose urine excretion rate,UI（ P〈0. 05）. Conclusion Rhubarb can adjust gastrin,improve D-xylose urine excretion and thus improve the gastrointestinal absorption function.
出处
《东南国防医药》
2016年第2期128-130,共3页
Military Medical Journal of Southeast China
基金
南京军区医学科技创新课题(09Z021)
