摘要
目的:研究健康志愿者口服大黄制剂后大黄酸在人体内的药代学过程。方法:12名健康自愿者单次口服大黄制剂(50mg.kg-1),分别在服药0,0.083,0.5,1,1.5,2,3,4,5,7,10h后11个不同时间点取静脉血,血药浓度采用高效液相色谱法(HPLC)测定,药代学参数采用3P97程序计算。结果:人口服大黄制剂后,大黄酸以很快的速度从肠道被吸收入血。其主要药代学参数为最大血药浓度(Cmax)(3.20±1.08)μg.mL-1;最大浓度时间(tmax)(1.03±0.41)h;分布半衰期(t1/2α)(0.21±0.02)h;消除半衰期(t1/2β)(2.68±1.09)h;平均滞留时间(MRT)(5.31±1.78)h;药时曲线下面积(AUC0-∞)(1573.08±366.48)μg.mL-1.min-1。结论:大黄制剂口服后大黄酸能迅速被人体吸收,其药代学符合二室模型。
Objective： To study the pharmacokinetics of rhein in 12 healthy volunteers after oral administration of rhubarb extract. Method： The blood sample were obtained at 0,0.083,0.5,1,1.5,2,3,4,5,7,10 h after a single dose oral administration of rhubarb extract （50mg·kg^-1）. The plasma rhein concentration was determined by HPLC. The pharmacokinetics of rhein were analysed by 3P97 program. Result： The absorption of rhein was very fastafter oral administration of rhubarb extract in the healthy volunteers. The main pharmacokinetic pararaeters of rhein were Cmax（3.20±08）μg·mL^-1; tmax（1.03 ±0.41） h; t1/2α（0.21 ±0.02） h; t1/2β（2.68±1.09） h; MRT（5.31 ± 1.78） h; AUC0-∞（ 1 573.08±366.48）μg·mL^-1·min^-1, respectively. Conclusion： Rhein could be absorbed rapidly and its phannacokinetics was consistent with two-compartment model.
出处
《中国中药杂志》
CAS
CSCD
北大核心
2005年第18期1458-1461,共4页
China Journal of Chinese Materia Medica
关键词
大黄酸
药代学
血浆
rhein
pharmacokinetics
plasma
