摘要
目的探讨少弱畸精子症患者结合单精子卵细胞浆内显微注射技术(ICSI)后的临床结局及安全性。方法回顾性分析2014年1月到2015年5月来我中心行辅助生殖治疗的508对夫妇经ICSI助孕后的临床结局。排除染色体核型异常、Y染色体微缺失、睾丸发育异常和FSH水平异常的干扰,根据精子来源和精液不同质量参数分为3组:A组,单纯梗阻性无精子症组,即PESA组;B组,少弱畸精子症组;C组,严重少弱畸精子症组。比较3组获卵数,正常受精率、卵裂率、可用胚胎率、种植率、妊娠率、生化妊娠率、流产率以及周期活产率等情况。结果 3组之间受精率、卵裂率、可用胚胎率、临床妊娠率、生化妊娠率、流产率以及周期活产率没有明显差异(P>0.05);但与A组相比,B组和C组其种植率显著降低(40.5%vs 50.0%,41.6%vs 50.0%,P<0.01);B组和C组之间则无统计学差异(40.5%vs41.6%,P>0.05)。结论少弱畸精子症及严重少弱畸精子症显著影响胚胎的种植率。
Objective To investigate the efficacy and security of oligoasthenoterazoospermia in assisted reproductive medicine. Methods Clinical outcomes of 428 couples who underwent ICSI from 1 st January 2014 to 31 st May 2014 were retrospectively analyzed. Excluding factors such as abnormal chromosome karyotype, Y chromosomal microdeletions, abnormal testicular development and abnormal FSH level, the patients were divided into 3 groups based on the source and the parameters of sperms, including Group A（obstructive azoospermia）, group B（oligoasthenoterazoospermia） and group C（severe oligoasthenoterazoospermia）. The fertilization rate, embryo cleavage rate, available embryo rate, embryo implantation rate, clinical pregnancy rate, biochemical pregnancy rate, abortion rate and live delivery rate were compared between the 3 groups. Results No significant differences were observed in fertilization rate, embryo cleavage rate, available embryo rate, clinical pregnancy rate, biochemical pregnancy rate, abortion rate and live delivery rate （P〉0.05） among three groups. As compared with that of the group A, the embryo implantation rates of group B and group C were significantly decreased （50.0% vs. 40.5%, 50.0% vs. 41.6%, respectively, P〈0.01）. No significant difference was observed between group B and group C （40.5% vs. 41.6%, P〉0.05）. Conclusion Oligoasthenoterazoospermia and severe ol significantly affect the embryo implantation rate
出处
《中国男科学杂志》
CAS
CSCD
2016年第2期21-25,共5页
Chinese Journal of Andrology
基金
国家自然科学基金(81370710
81300531)
唐都医院科技创新项目(2013CXTS015)
关键词
精子注射
细胞质内
不育
男性
妊娠率
sperm injections, intracytoplasmic
infertility, male
pregnancy rate
