摘要
DNA甲基化和组蛋白修饰是表观遗传学中控制基因表达的两个重要方式。UHRF1(Ubiquitin-like with PHD and ring finger domains 1)是近年来新发现的一种与细胞生长有关的核蛋白基因,是表观遗传学调控的"核心蛋白",是连接DNA甲基化和组蛋白修饰的重要纽带,可以通过其特殊的结构域识别表观遗传学标记并结合相应的催化酶,保证表观遗传标记从母细胞稳定遗传到子细胞。研究表明,UHRF1在多种肿瘤中表达异常,参与肿瘤细胞的增殖、侵袭和转移。本文重点介绍UHRF1调控表观遗传标记的分子机制,在肿瘤中的异常表达情况以及其在肿瘤诊治中应用的研究进展。
Epigenetics is a discipline focusing on maintenance of phenotype through successive mitosis and the mechanisms mainly include DNA methylation and histone modification.Ubiquitin-like with PHD and ring finger domains 1（UHRF1）is a unique molecule,which is a main ＂hub protein＂ involved in epigenetic information integration as well as links DNA methylation and histone modification to ensure faithful epigenetic memory inheritance. Recent researches suggest that UHRF1 overexpression is abundant in many kinds of cancers,and it is involved in cancer occurrence and progression. This paper reviews the mechanism of epigenetics as well as the progress of UHRF1 in tumor diagnosis and treatment.
出处
《南京医科大学学报（自然科学版）》
CAS
CSCD
北大核心
2016年第2期129-134,共6页
Journal of Nanjing Medical University(Natural Sciences)
基金
国家自然科学基金(21475063)
江苏省科技厅临床医学专项基金(BL2013036)
江苏省医学领军人才与创新团队基金(LJ201131)
关键词
表观遗传学
甲基化
组蛋白修饰
调控
肿瘤
epigenetics
methylation
histone modification
regulation
cancer
