摘要
目的:探讨UHRF1(Ubiquitin-like,containing PHD and RING finger domains 1)在肝细胞肝癌(hepatocellular carcinoma,HCC)中的表达及其与临床病理特征的关系。方法:采用免疫组织化学方法检测556例HCC组织及其癌旁组织中UHRF1的表达,分析其与HCC患者临床病理特征的关系。结果:免疫组织化学结果显示,UHRF1蛋白阳性表达定位于HCC细胞核,UHRF1蛋白在HCC组织中的表达显著高于癌旁组织。HCC组织中UHRF1蛋白阳性表达率为59%,其表达与肿瘤大小(P<0.01)、肿瘤分化(P<0.05)和微血管侵犯(P<0.01)相关。结论:HCC中UHRF1的表达与其恶性表型相关,UHRF1可能参与HCC的侵袭和转移。
Objective：To study the expression of UHRF1 and its relationships with the clinicopathological characteristics in hepatocellular carcinoma（HCC） .Methods ：The expression of UHRF1 was analyzed in 556 cases of tumor tissues and peritumor tissues of HCC by immunohistochemistry .The relationships of UHRF1 with the clinicopathological characteristics of HCC were assayed .Results：Immunohistochemistry showed that positive staining of UHRF1 located in the nucleus of HCC cells .The ex-pression levels of UHRF1 protein were higher in tumor tissues than in peritumor tissues .HCC patients with positive expression of UHRF1 protein accounted for 59% of the whole cohort .The expression of UHRF1 protein was significantly correlated with the size of tumor （ P〈0 .01） ,differentiation （P〈0 .05） and microvessel invasion（P〈0 .01） .Conclusions ：The overexpression of UHRF1 is correlated with the malignant phenotypes of HCC and probably implicated in the invasion and metastasis of HCC .
出处
《中国临床医学》
2014年第3期242-244,共3页
Chinese Journal of Clinical Medicine
基金
国家自然科学基金项目(编号:81071741)
上海市科委医学引导类项目(编号:114119a5000)
教育部新教师基金项目(编号:20090071120025)
关键词
肝细胞肝癌
UHRF1
临床病理特征
表观遗传学
Hepatocellular carcinoma
Ubiquitin-like, containing PHD and RING finger domains I
Clinicopathological characteristics
Epigenetics
